Urinary excretion of alpha 2 mu-globulin and albumin by adult male rats following treatment with nephrotoxic agents

Nephron
O W NeuhausC E Hollerman

Abstract

Nephrotoxic agents such as puromycin aminonucleoside (PAN) and sodium maleate (MAL) have been used to induce experimental glomerular proteinuria and tubular disease, respectively. Current studies show that PAN caused a massive loss of albumin in the urine while not affecting the excretion of the smaller, sex-dependent alpha 2 mu-globulin. On the other hand, MAL which inhibits the reabsorption of proteins, increased the loss of both alpha 2 mu and albumin. Both nephrotoxic agents increased the excretion of albumin when administered to female rats. MAL-induced proteinuria was used as a direct measure of the renal load for alpha 2 mu and albumin. Renal loads and excretion of alpha 2 mu and albumin were measured in male rats maintained on 0, 20, and 50% casein diets. On the protein-free diet, the excretion of both alpha 2 mu and albumin was reduced (less than 1 mg daily); their renal loads were almost totally reabsorbed. On a 50% casein diet the reabsorption of alpha 2 mu was reduced from a normal of 60% to 10% of the renal load. Thus the high protein diet increased the excretion of alpha 2 mu while having little effect on the excretion of albumin. We suggest that dietary protein exerts two levels of control on the excretion of pro...Continue Reading

Citations

Jan 1, 1987·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R L KanervaC L Alden
Jan 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Gumbleton, P J Nicholls
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G C Hard
Jan 1, 1988·Journal of Toxicology and Environmental Health·B D GargA K Roy
Aug 1, 1992·Journal of Toxicology and Environmental Health·M P DieterL C Uraih
Mar 1, 1996·Environmental Health Perspectives·R L MelnickC J Portier
Dec 1, 1991·Journal of Pharmacological Methods·L D Lehman-McKeeman, D Caudill
Jul 10, 2012·Expert Opinion on Drug Metabolism & Toxicology·Andrea TrevisanPatrizia Cristofori
Jan 1, 1994·Critical Reviews in Toxicology·G C Hard, J Whysner
Sep 14, 2011·Journal of Applied Toxicology : JAT·Patrizia CristoforiAndrea Trevisan
Mar 1, 1994·Toxicologic Pathology·R H AlisonD E Prentice
Mar 6, 2021·BMC Veterinary Research·Kanchana KengkoomSumate Ampawong
Apr 1, 1997·Toxicology and Applied Pharmacology·J S Prescott-MathewsS J Borghoff
Feb 1, 1991·Toxicology and Applied Pharmacology·S J BorghoffJ A Swenberg
Feb 1, 1991·Regulatory Toxicology and Pharmacology : RTP·W G Flamm, L D Lehman-McKeeman
Jan 1, 1989·Toxicology and Applied Pharmacology·J A SwenbergM Charbonneau
Jan 18, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Christian FleckGünter Stein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.