Urinary excretion of aquaporin-2 in the diagnosis of central diabetes insipidus

The Journal of Clinical Endocrinology and Metabolism
T SaitoT Saito

Abstract

We determined whether alteration in urinary excretion of aquaporin-2 (UAQP-2) is of value to diagnose central diabetes insipidus (CDI). First, UAQP-2 was determined in 16 normal subjects under ad libitum water drinking (n = 6) and after an overnight dehydration (n = 10). UAQP-2 has a positive correlation with plasma arginine vasopressin (AVP) levels (r = 0.61, P < 0.05) but not with urinary osmolality (Uosm). Second, a hypertonic saline (5% NaCl)-infusion test was studied in 5 normal subjects (21 to 25 yr old) and 10 patients with CDI (22-68 yr). After drinking water ad libitum, they were given 20 mL/kg water orally and then given 5% NaCl (0.05 mL/kg x min) i.v. for 120 min. Finally, 0.1 U of AVP was administered i.v. During the period, 30-min urine collections were made. In the normal subjects, after the infusion of 5% NaCl, plasma AVP levels and Uosm markedly increased in parallel with an increase in plasma osmolality (Posm, 294-320 mOsm/kg H2O; Uosm, 102-737 mOsm/kg H2O; AVP, 0.4-2.6 pg/mL, P < 0.001). In the CDI patients, plasma AVP and Uosm failed to increase, despite an increase in Posm (Posm, 306-332; Uosm, 102-164; AVP, 0.9-1.2). UAQP-2 was markedly greater in the normal subjects than the CDI patients (7.2 vs. 0.9 pmol/...Continue Reading

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Citations

Nov 21, 2008·BMC Urology·Charlotte Graugaard-JensenJens Christian Djurhuus
Dec 31, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elena A RodionovaMarina Zelenina
Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marina ZeleninaCharlotte Casper
Dec 14, 2011·Clinical and Experimental Nephrology·Sei SasakiMasahiro Muraguchi
Apr 16, 2013·Clinical and Experimental Nephrology·Justin L L WilsonMark A Knepper
Nov 13, 2002·Kidney International·Fuminori UmenishiRobert W Schrier
Nov 8, 2012·Veterinary Clinical Pathology·M Judith RadinMark A Knepper
Jul 31, 2010·The British Journal of Dermatology·Z H DiJ Xu
Oct 14, 2011·American Journal of Physiology. Renal Physiology·Carolina Cannillo GraffeErling Bjerregaard Pedersen
Dec 14, 2017·Physiological Reports·Charlotte Graugaard-JensenJens Christian Djurhuus
Aug 30, 2013·American Journal of Physiology. Renal Physiology·Yoshiki HigashijimaMasahiro Ikeda

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