Urinary excretion of benzo[a]pyrene metabolites following intravenous, oral, and cutaneous benzo[a]pyrene administration

Canadian Journal of Physiology and Pharmacology
M Bouchard, C Viau

Abstract

The effect of the administration route, dose, and sampling time on the total urinary excretion of four major benzo[a]pyrene (BaP) metabolites, 3-hydroxyBaP (3-OHBaP), 9-hydroxyBaP 9-hydroxyBaP (9-OHBaP), trans-4,5-dihydrodiolBaP (4,5-diolBaP), and trans-9,10-dihydrodiolBaP (9,10-diolBaP), was studied in male Sprague-Dawley rats exposed to a single intravenous, oral, and cutaneous dose of 2, 6, 20, and 60 mumol BaP/kg. Urine samples were collected at 24-h intervals following treatment. Over the 0-72 h period and for a given dose, amounts of BaP metabolites were 3-OHBaP > 4,5-diolBaP > > 9-OHBaP following intravenous and oral dosing, and 3-OHBaP > > 9-OHBaP > or = 4,5-diolBaP after cutaneous treatment. 9,10-diolBaP was barely detected. On the other hand, amounts of 3-OHBaP and 4,5-diolBaP excreted in urine over the 0-72 h period and for a given dose appeared in the following order: intravenous approximately oral > or = cutaneous. Amounts of 9-OHBaP excreted varied as follows: oral > or = cutaneous > intravenous. For all routes of administration, excretion of 4,5-diolBaP was almost complete over the 0-24 h period in contrast with 3-OHBaP and 9-OHBaP. Peak excretion of 3-OHBaP and 9-OHBaP was reached in the 0-24 h period following ...Continue Reading

Citations

Feb 3, 2016·Iranian Journal of Psychiatry and Behavioral Sciences·Asiyeh PirzadehAwat Feizi
Oct 12, 2007·Journal of Applied Toxicology : JAT·Caroline MarieJean-Luc Ravanat
Oct 29, 2014·Journal of Applied Toxicology : JAT·Marjory Moreau, Michèle Bouchard
Dec 17, 2014·Journal of Toxicology and Environmental Health. Part a·Marjory MoreauMichèle Bouchard
Jun 20, 2015·Journal of Toxicology and Environmental Health. Part a·Marjory MoreauMichèle Bouchard
Dec 6, 2005·Journal of Toxicology and Environmental Health. Part a·Dianxiu CaoSun Dong Yoo
Oct 30, 2004·International Journal of Toxicology·Aramandla RameshEric H Weyand
Oct 23, 2001·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·A RameshA M Nyanda

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