PMID: 6413813Apr 1, 1983Paper

Urinary excretion of carnitine in multiply injured patients on different regimens of total parenteral nutrition

Metabolism: Clinical and Experimental
G CederbladS O Liljedahl

Abstract

Carnitine derives from intake of preformed exogenous carnitine and synthesis from lysine and methionine, but is absent in parenteral fluids. Urinary excretions of carnitine and its derivatives was measured in 30 patients 2-8 days after severe multiple injuries and compared with controls. The patients received five different isocaloric parenteral nutritional regimens;group 1 glucose and fat, group 2 glucose, fat and amino acids, group 3 glucose and insulin, group 4 glucose and amino acids, and group 5 branched-chain amino acids. The mean total carnitine excretion in healthy men was 420 mumol/24 h +/- 57 (SEM), and in women 266 mumol/24 h +/- 29, 41% of which was free carnitine. Mean excretion of total carnitine during days 2-8 after trauma for the five groups was: 900 +/- 100, 1169 +/- 112, 1251 +/- 102, 1023 +/- 117, and 668 +/- 128 mumol/24 h, being significantly higher in groups 1-4 than in healthy men. The free carnitine fraction in the patients was significantly higher than in controlled healthy subjects. Total carnitine excretion was unaffected by different nutritional regimens in the very first days. During days 6-8, group 5, receiving branched-chain amino acids had lower excretion of total carnitine (compared to groups 2...Continue Reading

References

Aug 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·B KönigB Ross
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·L L Bieber, Y R Choi
Feb 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Khan, M S Bamji
Jan 15, 1979·Analytical Biochemistry·M Neuhäuser, P Fürst
Mar 30, 1978·Biochimica Et Biophysica Acta·D W Seccombe Novak
Sep 1, 1977·The Journal of Clinical Investigation·D RudmanJ D Ansley
Sep 6, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·M M Mikhail, M M Mansour
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J D McGarryD W Foster
Mar 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·G Cederblad, S Lindstedt
Nov 24, 1970·Biochimica Et Biophysica Acta·H E Solberg, J Bremer
Sep 1, 1980·JPEN. Journal of Parenteral and Enteral Nutrition·R C Tao, N N Yoshimura
Jan 1, 1981·The Journal of Nutrition·R C TaoN N Yoshimura
Nov 1, 1981·JPEN. Journal of Parenteral and Enteral Nutrition·V Tanphaichitr, N Lerdvuthisopon
Jul 1, 1981·Annals of Clinical Biochemistry·H ArnqvistS Wettre

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Citations

Apr 1, 1989·Journal of the American College of Nutrition·D J ScholtenR E Morgan
Apr 1, 1989·Journal of the American College of Nutrition·W L DodsonW Hanna
Apr 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S SandstedtJ Larsson
Aug 1, 1990·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M SoopJ Wahren
Nov 1, 1986·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·S SandstedtG Cederblad
Jul 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·G NanniM Castagneto
May 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·M H FischerJ A Marlett
Jan 1, 1988·JPEN. Journal of Parenteral and Enteral Nutrition·G IapichinoG Ronzoni
Jan 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·H Gilder
Sep 1, 2010·Evolutionary Applications·David L Van TasselThomas S Cox
Mar 1, 1984·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G CederbladB Schildt
Feb 1, 1992·Metabolism: Clinical and Experimental·A WennbergK Lundholm
Jul 1, 1986·Preventive Medicine·B S Kendler
Jun 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M SoopJ Wahren

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