Urinary excretion of dihydroxyphenylalanine and dopamine during alterations of dietary salt intake in humans

Clinical Science
D S GoldsteinJ R Gill

Abstract

1. Urinary excretion of dopamine (DA) increases during dietary salt loading. The majority of urinary DA is derived from circulating dihydroxyphenylalanine (dopa). Whether the increase in urinary DA excretion during salt loading results from increased efficiency of uptake of dopa by proximal tubular cells of the kidney, facilitation of intracellular conversion of dopa to DA, or increased delivery of dopa to tubular uptake sites, has been unknown. 2. In 10 inpatient normal volunteers on a constant diet, daily excretion of dopa and DA was assessed during normal sodium intake (109 mmol/day) for 1 week, low sodium intake (9 mmol/day) for 1 week and high sodium intake (249 mmol/day) for 1 week. 3. Urinary DA excretion exceeded urinary dopa excretion by about tenfold, and the excretion of both DA and dopa increased by about twofold between the low and high salt diets, with similar proportionate changes. Plasma dopa was unchanged by dietary salt manipulation. 4. The results indicate that increases in urinary DA excretion during dietary salt loading can be accounted for by increased delivery of dopa to sites of uptake by proximal tubular cells. Since dopa is released into the bloodstream by sympathetic nerve endings and by the brain, an...Continue Reading

Associated Clinical Trials

Citations

May 10, 2000·Clinical and Experimental Hypertension : CHE·P Soares-da-SilvaM Cerqueira-Gomes
Jan 1, 1994·Clinical and Experimental Hypertension : CHE·I SaitoT Sekihara
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FerreiraP Soares-Da-Silva
Jun 1, 1996·British Journal of Pharmacology·P C Pinto-do-O, P Soares-da-Silva
Jun 1, 1993·British Journal of Pharmacology·P Soares-da-Silva
Apr 1, 1992·British Journal of Pharmacology·P Soares-da-Silva, M H Fernandes
Jan 22, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·João S AmaralPatrício Soares-da-Silva
Jan 1, 1993·Fundamental & Clinical Pharmacology·M A Vieira-Coelho, P Soares-da-Silva
Aug 10, 2012·Experimental Biology and Medicine·Mónica Moreira-RodriguesManuel Pestana
Jun 8, 2004·American Journal of Physiology. Renal Physiology·Henry QuiñonesOrson W Moe
Oct 8, 1999·Journal of Autonomic Pharmacology·B Sampaio-MaiaP Soares-da-Silva
Sep 13, 2017·Clinical and Translational Science·David S GoldsteinYehonatan Sharabi
Oct 16, 1999·Hypertension·M A Vieira-CoelhoM F Lokhandwala
Dec 29, 1995·Annals of the New York Academy of Sciences·D S Goldstein
Feb 24, 2005·Journal of Cardiovascular Pharmacology·Margarida AlvelosPatrício Soares-da-Silva
Dec 22, 2009·The Journal of Clinical Hypertension·Alan B WederAmit Sachdeva
Feb 1, 2007·American Journal of Physiology. Renal Physiology·Maria João PinhoPatrício Soares-da-Silva
Jan 1, 1997·Clinical and Experimental Hypertension : CHE·P A JoseR A Felder
Jan 25, 2007·American Journal of Physiology. Renal Physiology·Agnès MaurelNathalie Pizzinat
Feb 22, 2013·American Journal of Physiology. Renal Physiology·Ming Chang HuOrson W Moe
Aug 11, 2004·European Journal of Heart Failure·Margarida AlvelosPatrício Soares-Da-Silva
Nov 30, 2000·American Journal of Physiology. Renal Physiology·M A Vieira-CoelhoP Soares-da-Silva
Jul 17, 1991·Journal of Chromatography·I ArmandoD S Goldstein
Oct 1, 1996·Diabetes Research and Clinical Practice·O SegersG Somers
Dec 5, 1998·Pharmacology & Therapeutics·P A JoseR A Felder
Sep 1, 1996·Kidney International·R G Woolfson, H E de Wardener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.