PMID: 3756113Sep 1, 1986Paper

Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether

British Journal of Industrial Medicine
D GroesenekenR Masschelein

Abstract

Ten healthy male subjects were exposed to ethylene glycol monoethyl ether (EGEE) under various conditions of exposure concentration and physical workload and their urinary excretion of ethoxyacetic acid was followed up for 42 hours. Maximal excretion of ethoxyacetic acid was reached three to four hours after the end of the four hour exposure period. Afterwards, ethoxyacetic acid excretion declined slowly with a biological half life of 21-24 hours. Ethoxyacetic acid excretion increased as the uptake of EGEE increased as a consequence of higher exposure concentration or pulmonary ventilation rate during physical exercise. On average, 23.1 +/- 6.3% of EGEE was recovered as ethoxyacetic acid within 42 hours and the recovery did not change as the uptake of EGEE increased. Quantitative relations between ethoxyacetic acid excretion and EGEE uptake were obtained and the relevance of ethoxyacetic acid excretion as a measure for exposure to EGEE is discussed.

References

May 1, 1978·Acta Pharmacologica Et Toxicologica·A K Jönsson, G Steen
Aug 1, 1986·British Journal of Industrial Medicine·D GroesenekenR Masschelein
Jan 1, 1986·British Journal of Industrial Medicine·D GroesenekenR Masschelein
Mar 1, 1971·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·D H Hutson, B A Pickering
Aug 1, 1984·Environmental Health Perspectives·K L CheeverW W Weigel
Aug 1, 1984·Environmental Health Perspectives·P M FosterT J Gray

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Citations

Oct 1, 1988·Toxicology Letters·G Johanson
Nov 5, 1997·The Journal of Emergency Medicine·D P DavisS R Williams
May 1, 1987·British Journal of Industrial Medicine·D GroesenekenE Van Vlem
Jul 1, 1987·British Journal of Industrial Medicine·D GroesenekenE Van Vlem
Aug 1, 1988·British Journal of Industrial Medicine·G Johanson, B Dynésius
Jan 1, 1993·British Journal of Industrial Medicine·H VeulemansD Groeseneken
Jan 1, 1997·Occupational and Environmental Medicine·S KezićF A de Wolff
Aug 26, 2003·Occupational and Environmental Medicine·C-H LohG-D Liao
Jan 1, 1989·International Archives of Occupational and Environmental Health·D GroesenekenE Van Vlem
Jan 1, 1989·International Archives of Occupational and Environmental Health·D GroesenekenE Van Vlem
Oct 18, 2015·International Journal of Hygiene and Environmental Health·Torka PoetSean M Hays
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Ivo IavicoliAlessandro Marinaccio
May 1, 1994·Human & Experimental Toxicology·R G Browning, S C Curry

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