Urinary excretion of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase in patients receiving amikacin or cis-platinum

Clinica Chimica Acta; International Journal of Clinical Chemistry
U DienerH Wisser

Abstract

Urinary excretion of alanine aminopeptidase (EC 3.4.11.2) and N-acetyl-beta-D-glucosaminidase (EC 3.2.1.30) was determined for 25-70 days in five patients receiving cis-platinum and for 8-53 days in six patients receiving amikacin. This study was performed to investigate if the excretion of urinary enzymes represents a sensitive parameter for the early detection of toxic kidney damage. The determination of N-acetyl-beta-D-glucosaminidase was carried out by the method of Knoll et al. [13]. The procedure of Mondorf et al. [14] for the estimation of alanine aminopeptidase activity was adapted to the Gemsaec Fast-Analyzer. In both patient groups an increase in the excretion of the two enzyme activities could be demonstrated. In patients receiving amikacin, the excretion of alanine aminopeptidase was always higher than that of N-acetyl-beta-D-glucosaminidase, whereas in three patients receiving cis-platinum it was the opposite. In two cis-platinum patients the excretion of both enzymes was of the same size. The changes during amikacin therapy seem to be reversible, whereas in four cis-platinum patients these changes seemed to be partly irreversible. Serum creatinine concentration was less sensitive than the urinary enzyme excretion ...Continue Reading

References

Aug 1, 1978·The American Journal of Medicine·N E Madias, J T Harrington
Mar 1, 1977·Toxicology and Applied Pharmacology·W E Stroo, J B Hook
Mar 24, 1977·The New England Journal of Medicine·G B Appel, H C Neu
Sep 1, 1979·Histochemistry·M Le HirU Schmidt
May 17, 1978·European Journal of Clinical Pharmacology·A W MondorfW Schoeppe
Sep 16, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·J E ScherberichG Pfleiderer
Dec 16, 1971·Biochimica Et Biophysica Acta·P Horácek, J Drobník

❮ Previous
Next ❯

Citations

Jan 1, 1986·Cancer Chemotherapy and Pharmacology·M P GorenM E Horowitz
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·J VerweijH M Pinedo
Jun 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·U DienerU Klotz
Jan 1, 1985·European Journal of Clinical Pharmacology·A S TirelliB M Assael
Jan 1, 1989·European Journal of Clinical Pharmacology·G DerayC Jacobs
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·U Metz-KurschelE Aulbert
Dec 31, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·N V LiubimovaL A Durnov
Jul 1, 1997·Biological Trace Element Research·T MinamiY Okazaki
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·G DerayC Jacobs
Jul 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·B H BrouhardT G Pollard
Oct 31, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·D MaruhnU Metz
Jul 16, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·K M RomeroR H Glew
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M C Sanchez-BernalJ A Cabezas
Dec 30, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·B JelakovićZ Krznarić
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Sushrut S Waikar, Joseph V Bonventre
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·E A SwabbD N McKinstry
Oct 1, 1987·Antimicrobial Agents and Chemotherapy·M J RybakL M Albrecht
Apr 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·F BarragánA Castelao
Mar 31, 1999·Nihon Ika Daigaku zasshi·K ObaS Metori
Jun 1, 1984·Biochemical Medicine·E N EllisL LaGrone
Jan 1, 1989·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F StriginiP Fioretti
Mar 14, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Sushrut S WaikarGlenn M Chertow
Dec 13, 2017·Experimental Biology and Medicine·Blessy GeorgeLauren M Aleksunes
Nov 1, 1992·Critical Reviews in Oncology/hematology·G Daugaard, U Abildgaard

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