Urinary Excretion of Niacin Metabolites in Humans After Coffee Consumption

Molecular Nutrition & Food Research
Jonathan Isaak KremerElke Richling

Abstract

Coffee is a major natural source of niacin in the human diet, as it is formed during coffee roasting from the alkaloid trigonelline. The intention of our study was to monitor the urinary excretion of niacin metabolites after coffee consumption under controlled diet. We performed a 4-day human intervention study on the excretion of major niacin metabolites in the urine of volunteers after ingestion of 500 mL regular coffee containing 34.8 μmol nicotinic acid (NA) and 0.58 μmol nicotinamide (NAM). In addition to NA and NAM, the metabolites N1 -methylnicotinamide (NMNAM), N1 -methyl-2-pyridone-5-carboxamide (2-Py), and nicotinuric acid (NUA) were identified and quantified in the collected urine samples by stable isotope dilution analysis (SIVA) using HPLC-ESI-MS/MS. Rapid urinary excretion was observed for the main metabolites (NA, NAM, NMNAM, and 2-Py), with tmax values within the first hour after ingestion. NUA appeared in traces even more rapidly. In sum, 972 nmol h-1 of NA, NAM, NMNAM, and 2-Py were excreted within 12 h after coffee consumption, corresponding to 6% of the ingested NA and NAM. The results indicate regular coffee consumption to be a source of niacin in human diet.

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Citations

Jun 1, 2019·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Christine Beedham
Mar 1, 2019·International Journal of Molecular Sciences·Valeria GasperiMaria Valeria Catani
Dec 19, 2018·Biochemical Society Transactions·Mikhail V MakarovMarie E Migaud
Jan 28, 2021·International Journal of Molecular Sciences·Faisal HayatMarie E Migaud
Nov 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simone StegmüllerElke Richling
May 21, 2021·Advances in Nutrition·Talha RafiqPhilip Britz-McKibbin

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Software Mentioned

Origin
Analyst
SIVA
Multiquant

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