Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children

International Urology and Nephrology
Tülay BecerirYaşar Enli

Abstract

Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR). The study included 88 children (31 males, 57 females) aged between 3 months and 18 years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1 + 2), children without RPS (Group 3 + 4), children with VUR (Group 1 + 3), and children without VUR (Group 2 + 4). We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5 pg/ml (min-max 0.0022-12.3668) vs. 2.2 pg/ml (min-max 0.0022-18.5868) and uPTX3/creatinine, 10.5 pg/m...Continue Reading

References

Jan 1, 1995·Current Topics in Pathology. Ergebnisse Der Pathologie·J A Roberts
Feb 9, 2000·Pediatric Surgery International·R S JutleyG K Ninan
Jan 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benedetta BussolatiGiovanni Camussi
Mar 21, 2003·European Journal of Immunology·Alma J NautaAnja Roos
Jan 28, 2005·Kidney International·Alma J NautaAnja Roos
Apr 6, 2006·Pediatrics·Emmanouil GalanakisMaria Kalmanti
Feb 6, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiaolin HeMingyao Liu
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Mengli TongMohamed E Suliman
Feb 13, 2008·Circulation·Monica SalioAlberto Mantovani
Feb 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna SabasiñskaTadeusz Porowski
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Gabrielle WilliamsJonathan C Craig
Dec 9, 2009·Annual Review of Immunology·Barbara BottazziAlberto Mantovani
Jan 20, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ibrahim GokceAhmet Topuzoglu
Mar 9, 2010·Nature Immunology·Livija DebanAlberto Mantovani
May 5, 2010·Annals of the Rheumatic Diseases·N BassiA Doria
Aug 5, 2010·Cell and Tissue Research·Livija DebanAlberto Mantovani
Jul 7, 2012·Clinical Transplantation·Naofumi ImaiIchiei Narita
Jan 18, 2013·Kidney International·Maciej LechHans-Joachim Anders
Dec 30, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Selçuk YükselNeşe Çallı Demirkan
Sep 2, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gönül ParmaksızNurcan Cengiz
Dec 13, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Tung-Wei HungHorng-Rong Chang

❮ Previous
Next ❯

Citations

Feb 4, 2021·Current Opinion in Pediatrics·Ian K Hewitt, Giovanni Montini

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.