Urinary excretion of prostacyclin and thromboxane metabolites in climacteric women: effect of estrogen-progestin replacement therapy

Prostaglandins
O YlikorkalaL Viinikka

Abstract

To study the role of vasodilatory prostacyclin and vasoconstrictory thromboxane A2 in climacteric vascular instabilities, overnight urine samples were collected from sixteen women suffering from hot flushes and sweating before, during and after the six months' cyclic estradiol-desogestrel therapy as well as from ten non-climacteric control women. The urine was assayed for 6-keto-PGF1a and 2,3-dinor-6-keto-PGF1a (metabolites of prostacyclin) as well as for thromboxane B2 and 2,3-dinor-thromboxane B2 (metabolites of thromboxane A2) by means of HPLC and radioimmunoassay. No difference was seen in baseline prostaroid output between the climacteric and non-climacteric study groups. Furthermore, no relation was observed between individual prostanoid excretion and severity of vasomotor symptoms before replacement therapy. The replacement therapy abolished or markedly alleviated hot flushes and sweating, but prostanoid output did not change. Our data imply that climacteric symptoms are not accompanied by changes in the production of prostacyclin and thromboxane A2.

References

Jul 1, 1980·Maturitas·I V TatarynH L Judd

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Citations

Jan 1, 1995·Journal of Thrombosis and Thrombolysis·E N Meilahn
Jul 13, 2000·European Journal of Drug Metabolism and Pharmacokinetics·C J TimmerA F Cohen
May 2, 1998·Brain Research·Y Q ZhangJ W Simpkins
Jun 27, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T MikkolaO Ylikorkala
Jan 23, 2009·Maturitas·Alfred O Mueck, Harald Seeger
Sep 30, 2008·Climacteric : the Journal of the International Menopause Society·D BruceO Ylikorkala
Jul 13, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alfred O Mueck, Harald Seeger
Jun 28, 2007·Menopause : the Journal of the North American Menopause Society·Alfred O MueckHarald Seeger

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