Urinary excretion of pyridinium cross-links of collagen in infancy

Metabolism: Clinical and Experimental
H TsukaharaM Sudo

Abstract

This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high-performance liquid chromatography (HPLC). Beta2-Microglobulin (beta2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary beta2M, and the values obtained did not correlate with beta2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal...Continue Reading

Citations

Apr 9, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Hany AlyKantilal Patel
Mar 21, 2008·Pediatrics International : Official Journal of the Japan Pediatric Society·Fatih M Kislal, Ugur Dilmen
Jan 1, 1997·International Journal of Clinical & Laboratory Research·R GfatterP Hackl
Mar 24, 1999·Pediatric Research·K E NaylorG L Klein
Mar 28, 2008·European Journal of Pediatrics·Laurent BonnemainsRegis Coutant
Dec 14, 2005·Early Human Development·Murat CakirAysenur Okten

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