Urinary excretion of testosterone and estradiol in Chinese men and relationships with serum lipoprotein concentrations

Metabolism: Clinical and Experimental
L S OoiJ R Masarei

Abstract

Urinary excretion of total and free testosterone and estradiol was measured in 46 healthy Chinese men, along with serum concentrations of total testosterone and estradiol and the calculated free (unbound) concentrations. Associations with serum concentrations of total, low-density lipoprotein (LDL), high-density lipoprotein-2 (HDL2), and HDL3 cholesterol, apolipoproteins (apos) A-I and B, lipoprotein(a) [Lp(a)] were studied. Serum total and free testosterone concentrations were positively correlated with HDL and HDL2 cholesterol and apo A-I. Serum total and free estradiol levels showed borderline-significant negative associations with total and LDL cholesterol levels. Among urinary variables, total estradiol excretion was negatively associated with apo B levels and showed borderline-significant associations with total and LDL cholesterol. Adjustment for potential confounders, including age, body mass index (BMI), and waist to hip ratio (WHR), strengthened the associations between urinary total estradiol and serum total cholesterol, LDL cholesterol, and apo B. Urinary free estradiol showed a significant correlation with HDL3 cholesterol. Urinary excretion of total testosterone was significantly negatively associated with serum c...Continue Reading

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Citations

Apr 6, 2004·Atherosclerosis·Peter Alexandersen, Claus Christiansen
Mar 12, 2003·Steroids·Nirmal S PanesarChung S Ho
Mar 19, 2014·The American Journal of Medicine·Anat Ben-ShlomoShlomo Melmed
Jan 3, 2001·Toxicology and Applied Pharmacology·N S Panesar, K W Chan
Jun 6, 2002·Diabetes, Obesity & Metabolism·R W C Pang, K S L Lam
Feb 6, 2018·The Open Orthopaedics Journal·Maja Fadzan, Josette Bettany-Saltikov
May 20, 2005·Endocrine Reviews·Jean M Kaufman, Alex Vermeulen

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