PMID: 8593760Jul 1, 1995Paper

Urinary excretion of type IV collagen and laminin in the evaluation of nephropathy in NIDDM: comparison with urinary albumin and markers of tubular dysfunction and/or damage

Diabetes Research and Clinical Practice
N BanuM Yamakido

Abstract

To clarify the diagnostic relevance of urinary type IV collagen (IV-C) and laminin in diabetic nephropathy, the excretion of these basement membrane proteins were determined by enzyme immunoassay in 172 non-insulin-dependent diabetic patients with different grades of nephropathy and 64 non-diabetic control subjects, and were evaluated in comparison with those of urinary albumin, N-acetyl-beta-D-glucosaminidase (NAG) and alpha 1-microglobulin (alpha 1MG). These excretions were also compared between a group of non-diabetic renal disease (NDRD) patients (n = 24) and a subgroup of the diabetic patients studied (n = 76), whose urinary albumin excretion (UAE) varied within the ranges of micro- and macroalbuminuria. Of the diabetic patients studied, 49.7%, 53.4% and 32.4% had raised urinary albumin, NAG and alpha 1 MG excretion, respectively. In these patients, 54% and 53% exceeded the upper limit of normal for urinary IV-C and laminin. The level of IV-C and laminin excretion and the prevalence of their abnormal excretion showed a trend to increase with increasing grade of nephropathy, as assessed by UAE. In the normoalbuminuric [UAE < 20 mg/g creatinine (Cr)] stage, 28.3% and 26.3% patients had raised urinary IV-C and laminin excreti...Continue Reading

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Citations

Feb 22, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna SabasiñskaTadeusz Porowski
Mar 1, 1996·Diabetes Research and Clinical Practice·S KadoN Nagata
Jan 27, 1998·Journal of Diabetes and Its Complications·C Y Hong, K S Chia
Jun 18, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tetsunori SaikawaUNKNOWN DDV investigators
Nov 17, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Mai YanagiSatoshi Umemura
May 31, 2012·International Journal of Nephrology·Abraham Cohen-Bucay, Gautham Viswanathan
Mar 1, 2003·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Michimasa KobayashiYasuhiko Tomino
May 9, 2012·Clinical and Experimental Hypertension : CHE·Daijiro EnomotoJitsuo Higaki
Mar 2, 2011·Proteomics. Clinical Applications·Christelle FoucherDarren Wilbraham
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Mar 15, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rafael N MorescoGuilherme V Bochi
Jul 15, 2016·Journal of Diabetes Research·Cristina GluhovschiBogdan Timar
Jun 15, 2010·Diabetes Research and Clinical Practice·Pisut KatavetinSomchai Eiam-Ong
Sep 29, 2017·Critical Reviews in Clinical Laboratory Sciences·Nektaria Papadopoulou-MarketouIoannis Papassotiriou

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