PMID: 6106975Sep 1, 1980Paper

Urinary gamma-glutamyl transferase as a specific marker for mercury after heavy metal treatment of rats

Toxicology Letters
P J Dierickx

Abstract

Male Sprague--Dawley rats were injected i.p. with 1 mg heavy metal (Cu, Rb, Cs, Zn, Sr, Cd, Ba, Zr, Pb, Mb, Fe, Co, Ni)/kg body weight, as chlorides and 24 h urine samples were analysed for gamma-glutamyl transferase (GGT) content. Mercury (Hg) was the only metal that induced an enhanced urinary GGT activity. We concluded that, when acute metal intoxication has been observed, urinary GGT may function as a specific marker for Hg intoxication. Gel permeation studies showed that increased tubular lesion accounts for the Hg-induced GGT increase.

References

Nov 1, 1976·Bulletin of Environmental Contamination and Toxicology·L C KingE J Faeder
Jul 1, 1973·Journal of the National Cancer Institute·S Fiala, E S Fiala
Sep 16, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·J E ScherberichG Pfleiderer

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Citations

Jan 1, 1991·Journal of Biochemical Toxicology·C B Houghton, M G Cherian
May 1, 1991·Biological Trace Element Research·S KhandelwalS K Tandon
Oct 15, 1988·The Science of the Total Environment·B PatelS Patel
Mar 1, 1981·Toxicology Letters·P J Dierickx, J O de Beer
Feb 1, 1982·Toxicology Letters·V Burgat-SacazeA Rico
Sep 26, 2014·Biological Trace Element Research·Alexey A TinkovAnatoly V Skalny
Jan 1, 1996·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·A TrevisanS Maso
Dec 1, 1992·Biological Trace Element Research·S GhoshG Talukder
Dec 1, 1992·Chemico-biological Interactions·A AlboresA J Zelazowski

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