PMID: 3760785Aug 1, 1986Paper

Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat

Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie
D A FeinfeldR Safirstein

Abstract

Rats given a single toxic dose of cisplatin all developed detectable glutathione-S-transferase activity in their urine between the third and fifth day after injection of cisplatin, simultaneously with the decreased urine osmolality and increased urine volume characteristic of cisplatin nephrotoxicity. Peak urinary glutathione-S-transferase levels occurred at the same time as maximal serum creatinine levels, and there was a significant statistical correlation between these two variables. These findings suggest that urinary glutathione-S-transferase activity is a marker for proximal renal tubular injury from cisplatin.

References

Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W H HabigW B Jakoby
Mar 1, 1972·The Journal of Clinical Investigation·G FleischnerI M Arias

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Citations

Jan 1, 1996·Free Radical Biology & Medicine·K Jung, W Henke
Jul 11, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mahmoud A MansourOthman A Al-Shabanah
Nov 20, 2002·Anti-cancer Drugs·Carla FenoglioMaurizio Viale
Mar 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Swen N PiperJoachim Boldt
Nov 14, 2013·British Journal of Clinical Pharmacology·Leonie van MeerJacobus Burggraaf
Apr 14, 2005·Life Sciences·Osama A BadaryGehan H Owieda

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