Urinary human L-FABP is a potential biomarker to predict COX-inhibitor-induced renal injury

Nephron. Experimental Nephrology
Tamami TanakaToshiro Fujita

Abstract

A strong demand exists for the development of sensitive biomarkers in the nephrology field. We propose urinary human L-type fatty acid binding protein (L-FABP) as an earlier biomarker to detect the outcome of chronic renal injury induced by cyclooxygenase (COX) inhibitors using human L-FABP transgenic mice. After consuming a low-sodium diet for 2 weeks, transgenic mice were administered meloxicam or celecoxib with the low-sodium diet. Mice were sacrificed 2 days and 4 weeks after starting COX inhibitors, and urine was collected 24 and 48 h and 1, 2, 3, and 4 weeks after starting COX inhibitors. Celecoxib-treated mice were divided into responders or nonresponders according to urinary L-FABP levels, and histology, urinary L-FABP and peritubular capillary blood flow were evaluated. Meloxicam-treated mice showed a higher blood pressure than control mice. Urinary L-FABP was significantly increased in COX inhibitor-treated mice. Peritubular capillary blood flow in all meloxicam-treated mice and in some celecoxib-treated mice was significantly decreased. Although blood urea nitrogen was not increased, interstitial fibrosis and macrophage infiltration were revealed, especially in meloxicam-treated mice. Responders showed an increase of...Continue Reading

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Citations

Nov 21, 2008·American Journal of Physiology. Renal Physiology·Eisei NoiriTakeshi Sugaya
Mar 24, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yao XuShan Mou
Mar 20, 2013·Toxicology and Applied Pharmacology·Rachel P L van SwelmFrans G M Russel
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Mar 7, 2009·The American Journal of Pathology·Tamami TanakaEisei Noiri
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Yoshifumi HamasakiEisei Noiri

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