Urinary IL-6/EGF ratio: a useful prognostic marker for the progression of renal damage in IgA nephropathy

Kidney International
E RanieriF P Schena

Abstract

Interleukin 6 (IL-6) is produced by human mesangial and tubular cells, and its urinary levels has been proposed as a marker of mesangial proliferation and tubulointerstitial damage. Epidermal growth factor (EGF) is expressed within the Henle's loop and the distal tubule and has been shown to accelerate recovery from renal injury. In the present study we have defined renal gene and protein expression of IL-6 and EGF in 10 normal, 10 nonproliferative glomerulonephritis (NPGN) and 30 IgA nephropathy (IgAN) human kidneys by RT-PCR, in situ hybridization and immunohistochemical techniques. Moreover, urinary IL-6 and EGF levels were measured in 41 patients with IgAN and in 20 normal subjects (N). In normal kidneys, EGF was localized in Henle's loop and distal convoluted tubule whereas IL-6 was mainly located in the proximal tubule and, less, within the glomerulus. In IgAN patients, EGF was decreased whereas IL-6 expression was upregulated. These modifications paralleled the degree of tubulointerstitial damage. Moreover, IgAN patients as a whole exhibited a reduction of EGF and an increase of IL-6 urinary concentration (EGF values: N, 12.96 +/- 1.15; IgAN Grades 1-2, 20.05 +/- 2.64; Grades 3-4 7.60 +/- 1.70: Grade 5, 3.14 +/- 0.71, ng...Continue Reading

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
Dec 1, 1992·The American Journal of Physiology·I SabolićD Brown
Mar 1, 1992·Kidney International·D L Coleman, C Ruef
Aug 1, 1992·The Journal of Urology·G WaltonI S Sawczuk
Jan 1, 1991·American Journal of Nephrology·Y TominoH Koide
Jun 1, 1991·Annals of Hematology·J Bauer, F Herrmann
Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P R GoodyerC G Goodyer
Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R C Harris
Dec 1, 1990·Immunology Today·T HiranoT Kishimoto
Jun 1, 1990·Kidney International·R SafirsteinR C Harris
Aug 1, 1990·The Journal of Clinical Investigation·S J BrandtA W Nienhuis
Jan 1, 1989·Annual Review of Physiology·D A FisherL Barajas
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MilaniH Stein
Jan 1, 1988·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G D'Amico
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Sep 1, 1988·The Journal of Clinical Investigation·R C HarrisK F Badr
Jan 1, 1995·Contributions to Nephrology·L GesualdoF P Schena
Jan 1, 1994·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A C Ong, L G Fine
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T TairaS Koshikawa
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A C Ong, L G Fine
May 1, 1993·European Journal of Clinical Investigation·L G FineJ T Norman
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M H RaasveldR J ten Berge
Jan 1, 1993·Kidney International·H E Abboud

❮ Previous
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Citations

Jul 11, 2007·World Journal of Urology·Bruce A JulianJan Novak
Aug 19, 2007·World Journal of Urology·Stephane DecramerJoost P Schanstra
Aug 15, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J J Pestka, H R Zhou
Apr 3, 2013·Nature Reviews. Nephrology·Jürgen Floege, John Feehally
Mar 19, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Rieko NagaokaYuichiro Yamashiro
Mar 11, 2004·La Revue du praticien·Eric Alamartine
Nov 14, 2001·Current Opinion in Nephrology and Hypertension·W Wong, A K Singh
Mar 9, 2005·Kidney International. Supplement·Kar Neng LaiJoseph C K Leung
Mar 19, 2005·Nephron. Experimental Nephrology·Nicoletta RondaCarlo Buzio
Nov 19, 2013·Cellular & Molecular Immunology·Cristen B ChafinChristopher M Reilly
Oct 25, 2012·Annual Review of Pathology·Jiri MesteckyJan Novak
Oct 15, 2014·Nature Reviews. Nephrology·Helena M KokTri Q Nguyen
May 11, 2005·Kidney International·Marion HaubitzHarald Mischak
Jan 16, 2008·Kidney International·F W Ballardie, R D Cowley
Feb 13, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sandrine FlorquinJan J Weening
Dec 4, 2015·Science Translational Medicine·Wenjun JuUNKNOWN ERCB, C-PROBE, NEPTUNE, and PKU-IgAN Consortium
Oct 6, 2015·SpringerPlus·Maria Fernanda SoaresM F Franco
May 6, 2016·Frontiers in Immunology·Barbora KnoppovaJan Novak
May 5, 2016·Journal of Nephrology·Dita MaixnerovaVladimir Tesar
Feb 12, 2019·Annual Review of Physiology·William R Zhang, Chirag R Parikh
Apr 20, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Maria Teresa RocchettiLoreto Gesualdo
Oct 19, 2013·Experimental and Therapeutic Medicine·Zhu ZhangGuangling Zhu
Oct 19, 2013·Experimental and Therapeutic Medicine·Minghui SongAnjun Li
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C S LimJ W Noh
Mar 16, 2000·Renal Failure·E N Wardle
Feb 2, 2002·The Journal of Nutrition·James J PestkaAnn M Timmer
Jun 28, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Baihong LiJie Ding
Sep 7, 2020·Arthritis & Rheumatology·Juan M Mejia-ViletBrad H Rovin
Jun 11, 2002·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·S Decramer
Nov 25, 2003·Seminars in Nephrology·Jun WadaHirofumi Makino

❮ Previous
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