Urinary incontinence following deep brain stimulation of the globus pallidus internus: case report

Journal of Neurosurgery
Feng-Tao LiuJian-Jun Wu

Abstract

Deep brain stimulation (DBS) is a well-established therapy for patients with advanced Parkinson's disease (PD), dystonia, and other movement disorders. In contrast to the strong positive effects that have been documented for motor symptoms, the effects of DBS on nonmotor symptoms have not been fully elucidated. Some reports suggest that stimulation of the subthalamic nucleus may improve lower urinary tract symptoms in patients with PD; however, reports of the effects of globus pallidus internus (GPi) DBS on urinary symptoms are limited. The authors present the case of a 49-year-old woman with PD who developed severe urinary incontinence after 27 months of GPi DBS. The urinary incontinence disappeared when stimulation was turned off, and reemerged after it was turned on again. After activation of a more dorsal contact in the left electrode, the patient's urinary dynamics returned to normal.

References

Aug 10, 2007·European Urology·Thomas M KesslerAlain Kaelin-Lang
Jul 6, 2014·Parkinsonism & Related Disorders·Livio MordasiniAlain Kaelin-Lang
Mar 27, 2015·Neurourology and Urodynamics·Ryuji SakakibaraUNKNOWN Parkinson's Disease Subcomittee, The Neurourology Promotion Committee in The International Continence Society
May 14, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Stephen MockChristopher M Tolleson
Nov 11, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ryuji SakakibaraTomonori Yamanishi
Jan 26, 2018·Annals of Neurology·Zhen NiRobert Chen
Mar 7, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Jose-Alberto Palma, Horacio Kaufmann
Mar 25, 2018·Neurology·Holly A RoyAlexander L Green
Dec 6, 2018·Movement Disorders Clinical Practice·Anne Pavy-Le TraonUNKNOWN Members of the MDS Committee on Rating Scales Development

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