Urinary iodine excretion and serum thyroid function in adults after iodinated contrast administration

Thyroid : Official Journal of the American Thyroid Association
Sun Y LeeAngela M Leung

Abstract

Iodinated contrast media (ICM) is a source of excess iodine that may induce thyroid dysfunction. A prospective cohort study was conducted to assess the effects of ICM on urinary iodine clearance and serum thyroid function tests (TFTs) in adults. In this prospective cohort study of 54 adults undergoing elective computed tomography (CT) scans at an academic medical center, serial urinary iodine concentrations (UIC) and serum TFTs were obtained until UIC normalized following ICM administration. Thyroid volume/nodularity were assessed by ultrasound. Associations between covariates and peak UIC, duration for UIC to peak and normalize, and thyroid dysfunction risk were assessed. The mean±standard deviation (SD) iodine administered was 34.6±6.0 g. Baseline median (range) UIC was 105.1 (17.0-866.1) μg/L, and serum thyrotropin (TSH) concentration was 1.26 (0.5-11.2) mIU/L. The mean±SD times to achieve peak UIC (median [range]: 3519 [233-157,500] μg/L] and normalized UIC were 1.1±0.5 and 5.2±4.0 weeks, respectively. Four subjects had elevated baseline TSH, and one had missing baseline TSH values. Of the remaining 49 subjects, 11 (22%) developed an abnormal TSH within one to four weeks (six elevated and five decreased). Administered iodin...Continue Reading

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Citations

Jan 29, 2020·Scandinavian Journal of Clinical and Laboratory Investigation·Thomas BøhmerSara Salehi Hammerstad
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Oct 13, 2016·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Philip O Anderson
Jun 9, 2018·Thyroid : Official Journal of the American Thyroid Association·Kosuke InoueBeate R Ritz
Mar 28, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees
Jun 19, 2016·Thyroid : Official Journal of the American Thyroid Association·Edy KorneliusChien-Ning Huang
Dec 23, 2015·The British Journal of Radiology·Babs M F HendriksMarco Das
Apr 9, 2019·Case Reports in Cardiology·Jelena Z ArnautovicRandy Ip
Jan 26, 2020·Journal of Clinical Medicine·Maha HichriBéatrice Cambien
Nov 18, 2020·European Journal of Clinical Nutrition·Elizabeth N Pearce
Feb 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Karen Tsai, Angela M Leung
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Si Hai-LongZhao Bing-Rang
Oct 21, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Georges VassauxBéatrice Cambien
Sep 30, 2021·The Journal of Nutrition·Bernadette L DekkerAnneke C Muller Kobold

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SAS

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