Urinary JCV-DNA testing during natalizumab treatment may increase accuracy of PML risk stratification.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Alice LaroniO E Varnier

Abstract

The risk of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab for multiple sclerosis (MS) is a serious concern. The presence of anti-JC virus antibodies is a risk factor for PML development, but 2.5 % of the patients result falsely-negative, while the prognostic relevance of testing JCV-DNA in biological fluids of treated patients is debated. Aim of this work was to evaluate the utility of testing JCV-DNA, together with anti-JCV antibodies, in biological samples of treated patients as a tool for PML risk stratification. 126 subjects from 5 MS Centers in Italy were included in the study. We performed a cross-sectional study in 63 patients testing JCV-DNA in blood, peripheral blood cells and urine. We longitudinally assessed the presence of JCV-DNA in a cohort of 33 subjects, one of which developed PML. We could test retrospectively serum samples from another PML case occurred during natalizumab therapy. Anti-JCV antibodies and urinary JCV-DNA were both tested in 73 patients. No changes in JCV-DNA status occurred during natalizumab treatment. The subject who developed PML in the longitudinal cohort had detectable JCV-DNA in urine at all time-points while serum or blood from both PML patients we...Continue Reading

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Citations

Dec 13, 2012·Journal of Translational Medicine·Roberta MancusoMario Clerici
Jun 20, 2014·CNS Drugs·Carmen Tur, Xavier Montalban
Aug 28, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Maria Inmaculada Dominguez-MozoRoberto Alvarez-Lafuente
Mar 2, 2013·Expert Review of Neurotherapeutics·Annika DeißMathias Buttmann
Jul 24, 2014·Journal of Neurovirology·Serena DelbuePasquale Ferrante
Jun 21, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hans H HirschCeline Leboeuf
May 21, 2016·Journal of Neurovirology·Milton H Werner, DeRen Huang
Nov 6, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Robert L CarruthersBrian C Healy
Dec 4, 2014·Arquivos de neuro-psiquiatria·Luiz Henrique da Silva NaliAugusto Cesar Penalva de Oliveira
Sep 16, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eric M L Williamson, Joseph R Berger
May 24, 2014·Journal of Central Nervous System Disease·Robert HoepnerAndrew Chan
Dec 16, 2018·Journal of Clinical Immunology·Jérôme HadjadjFelipe Suarez
May 12, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Qichen ZhangJingyuan Xiong

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