Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis?

Scientific Reports
Laura Gonzalez-CaleroGloria Alvarez-Llamas

Abstract

Implementation of therapy for acute kidney injury (AKI) depends on successful prediction of individual patient prognosis. Clinical markers as serum creatinine (sCr) have limitations in sensitivity and early response. The aim of the study was to identify novel molecules in urine which show altered levels in response to AKI and investigate their value as predictors of recovery. Changes in the urinary proteome were here investigated in a cohort of 88 subjects (55 AKI patients and 33 healthy donors) grouped in discovery and validation independent cohorts. Patients' urine was collected at three time points: within the first 48 h after diagnosis(T1), at 7 days of follow-up(T2) and at discharge of Nephrology(T3). Differential gel electrophoresis was performed and data were confirmed by Western blot (WB), liquid chromatography/mass spectrometry (LC-MS/MS) and enzyme-linked immunosorbent assay (ELISA). Retinol binding protein 4 (RBP4) and kininogen-1 (KNG1) were found significantly altered following AKI. RBP4 increased at T1, and progressively decreased towards normalization. Maintained decrease was observed for KNG1 from T1. Individual patient response along time revealed RBP4 responds to recovery earlier than sCr. In conclusion, KNG1 ...Continue Reading

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Citations

Oct 5, 2017·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marta Martin-LorenzoGloria Alvarez-Llamas
Jul 10, 2018·The Journal of Pathology·Cristian González-GuerreroAdrián M Ramos
Jun 20, 2020·Environmental Science and Pollution Research International·Lorena Díaz de León-MartínezRogelio Flores-Ramírez
Aug 23, 2017·Scientific Reports·Marta Martin-LorenzoGloria Alvarez-Llamas
Jun 21, 2019·JCI Insight·Paul PercoUNKNOWN Nephrotic Syndrome Study Network (NEPTUNE)
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio G Hernandez-LeonLuz Vazquez-Moreno
Apr 21, 2021·Journal of Ethnopharmacology·Sheng ZhangShen Ji

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Methods Mentioned

BETA
electrophoresis
ELISA
biopsy

Software Mentioned

SPSS
4000 Series
Mascot
Mass Hunter
IDIVAL
GraphPad Prism
ABSciex
Biological Variation Analysis ( BVA
GPS explorer
DeCyder Differential Analysis

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