Urinary Lead Concentration Is an Independent Predictor of Cancer Mortality in the U.S. General Population

Frontiers in Oncology
Sen LiLing Dong

Abstract

Lead is a ubiquitous pollutant that constitutes an environmental hazard worldwide. Although lead has been known as a carcinogenic factor in animal models, its role in human carcinogenesis is still a topic of debate with limited epidemiological evidence. Moreover, the association between urinary lead, as the most non-invasive and accessible way for lead measurement in human, and cancer mortality in general population has never been explored. We addressed this subject using continuous National Health and Nutrition Examination Survey 1999-2010 data and its Mortality Follow-Up Study. Of 5,316 subjects in study population, 161 participants died due to cancer. Cancer-specific mortality was associated with urinary lead levels after multivariable adjustment. Kaplan-Meier survival curve and cubic regression spline analyses indicated that high concentration of urinary lead exhibited significant association with raised death rate of cancer. Despite the marked decrease in environmental lead levels over the past three decades, lead exposure is still the significant determinant of cancer mortality in general population in U.S., and quantification of urinary lead may serve as a non-invasive approach to facilitate biomarker discovery and clini...Continue Reading

References

Aug 1, 1991·Current Opinion in Biotechnology·J A TainerE D Getzoff
Jan 1, 1992·Drug Metabolism Reviews·E J Calabrese, L A Baldwin
Dec 1, 1995·Scandinavian Journal of Work, Environment & Health·A AnttilaK Hemminki
Dec 11, 1999·International Archives of Occupational and Environmental Health·Y FukuiM Ikeda
Mar 4, 2000·The Science of the Total Environment·K HigashikawaM Ikeda
Aug 15, 2000·American Journal of Industrial Medicine·S Hernberg
Aug 15, 2000·American Journal of Industrial Medicine·K Steenland, P Boffetta
Sep 19, 2000·Environmental Research·H L Needleman
Apr 10, 2002·Environmental Health Perspectives·Ahmedin JemalKatherine M Flegal
Nov 20, 2002·Archives of Internal Medicine·Mark Lustberg, Ellen Silbergeld
May 15, 2003·Endocrinology·Mary Beth MartinAdriana Stoica
Jun 11, 2003·Nature Genetics·Yong Hwan JinDmitry A Gordenin
Apr 7, 2005·Environmental Health Perspectives·Marija PopovicWendy E Kaye
Sep 26, 2006·Environmental Research·Marie VahterMarika Berglund
Jan 11, 2007·Human & Experimental Toxicology·K P MishraSita Naik
Apr 14, 2007·Environmental Health Perspectives·Brian S Schwartz, Howard Hu
Sep 25, 2008·Cadernos de saúde pública·Maria de Fátima Ramos Moreira, Eduardo Borba Neves
Mar 10, 2009·Environmental Health Perspectives·Andy MenkeEliseo Guallar
Apr 7, 2009·Environmental Health : a Global Access Science Source·Naila KhalilJane A Cauley
Apr 14, 2009·Toxicology and Applied Pharmacology·Celia ByrneMary Beth Martin
Jan 21, 2010·Statistics in Medicine·Loic Desquilbet, François Mariotti
Mar 3, 2010·Biological Trace Element Research·Olusegun I Alatise, Gerhard N Schrauzer
Feb 5, 2011·Epidemiology·Dana M van BemmelPreetha Rajaraman
Jul 27, 2011·Journal of Occupational and Environmental Medicine·Elissa WilkerHoward Hu
Nov 10, 2011·Occupational and Environmental Medicine·Scott V AdamsPolly A Newcomb
Jan 31, 2012·Annals of Epidemiology·StellaMay GwiniMalcolm Ross Sim
Mar 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rick Chappell
Oct 10, 2012·International Journal of Hygiene and Environmental Health·Krista L Yorita Christensen
Nov 16, 2012·Journal of Toxicology and Environmental Health. Part a·Yu-Sheng LinBabasaheb Sonawane
May 3, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Omar HyderTimothy M Pawlik
Jan 1, 2001·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals· A Karakaya Z Karaaslan Y Duydu B Yücesoy G Oflaz S K Köse
Sep 5, 2013·Journal of Exposure Science & Environmental Epidemiology·Scott V Adams, Polly A Newcomb
Feb 18, 2014·Environmental Health Perspectives·Esther García-EsquinasAna Navas-Acien
Jul 15, 2015·Journal of Exposure Science & Environmental Epidemiology·Tsung-Lin TsaiShu-Li Wang

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Citations

Dec 8, 2019·Environmental Science and Pollution Research International·Aleksandra RepićZorica Bulat
May 14, 2020·Journal of Environmental Health Science & Engineering·Maryam EbrahimiNima Rezaei
Nov 28, 2020·Biological Trace Element Research·Reza TabriziHamed Akbari
Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps

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Methods Mentioned

BETA
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R
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