Urinary Lithogenic Risk Profile in ADPKD Patients Treated with Tolvaptan.

Clinical Journal of the American Society of Nephrology : CJASN
Matteo BargagliDaniel Fuster

Abstract

Nephrolithiasis is a common health problem in autosomal dominant polycystic kidney disease (ADPKD) and significantly contributes to patient morbidity. Recently, Tolvaptan has been introduced for the treatment of ADPKD, but whether it is associated with alterations of the urinary lithogenic risk profile remains unknown. We conducted an analysis of participants enrolled in the Bern ADPKD registry, a prospective observational cohort study. Twenty-four-hour urine analyses were performed at baseline and then at yearly follow-ups. Relative supersaturation ratios for calcium oxalate, brushite, and uric acid were calculated with the program EQUIL2. Unadjusted and multivariable mixed-effects linear regression models, adjusted for age, sex, body mass index, eGFR, net acid excretion, and height-adjusted total kidney volume, were used to assess the association of Tolvaptan with urinary parameters relevant for kidney stone formation. The maximum individual follow-up time was 3 years, median follow-up time 1.9 years, and cumulative follow-up time 169 years. In total, 125 participants (38 with and 87 without Tolvaptan treatment) were included in the analysis. In multivariable analysis, Tolvaptan treatment was associated [adjusted estimate of ...Continue Reading

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Citations

Jun 13, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Ewout J Hoorn, Robert Zietse
Aug 5, 2020·Clinical and Experimental Nephrology·Iris W KoorevaarNiek F Casteleijn
Jul 9, 2021·Therapeutics and Clinical Risk Management·Ioannis Bellos
Jun 26, 2021·KI Reports·Matteo BargagliDaniel Fuster

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