Urinary lysophopholipids are increased in diabetic patients with nephropathy

Journal of Diabetes and Its Complications
Jean-Sébastien Saulnier-BlacheJoost P Schanstra

Abstract

Diabetic nephropathy (DN) is a major cause of chronic kidney disease that frequently leads to end stage renal failure. Lysophosphatidic acid (LPA) and lysophosphatidylcholine (LPC) are lysophospholipid mediators shown to accumulate in kidney and to promote renal inflammation and tubulo-interstitial fibrosis in diabetic rodent models. Here we assessed whether LPA and LPC were associated to the development of nephropathy in diabetic human patients. Several molecular species of LPA and LPC were quantified by LC/MS-MS in urine and plasma from type 2 diabetic patients with (cases; n=41) or without (controls, n=41) nephropathy symptoms (micro/macro-albuminuria and eGFR<60ml/min/1.73m(2)). Cases and controls were matched for sex, age and diabetes duration. Six species were detected in urine for both LPA and LPC, LPA16:0, LPA20:4, LPC16:0, LPC18:0, LPC18:1, and LPC18:2 that were significantly more concentrated in cases than in controls. Total LPC and LPA (sum of detected species) were significantly and exclusively associated with albuminuria (P<0.0001 and P=0.0009 respectively) and were significantly higher in the 3rd when compared to the 1st albuminuria tertile in cases. Plasma lysophospholipids showed a different species profile urin...Continue Reading

Citations

Jun 20, 2019·International Journal of Molecular Sciences·Jong Han LeeHee-Sook Jun
Jul 14, 2020·Frontiers in Endocrinology·Biyu HouGuanhua Du
Oct 28, 2018·International Journal of Molecular Sciences·Lucille StuaniJustine Bertrand-Michel
Jul 21, 2020·Mediators of Inflammation·Mahmoud EmaraDalia H Abou-Elela
Sep 25, 2017·Physiological Genomics·Frank Park, Duane D Miller
Dec 6, 2020·The Journal of Pharmacology and Experimental Therapeutics·Takashi HirataRichard J Roman
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Opeyemi Joshua OlatunjiYifeng Zhou

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