PMID: 6024192May 26, 1967Paper

Urinary metabolites in congenital hyperuricosuria

Science
M E BalisJ Dancis

Abstract

The excretion of oxypurine metabolites in urine of patients with congenital hyperuricosuria exceeds, on a creatinine basis, that observed in any previously recognized metabolic anomaly. The ratio of hypoxanthine to xanthine is from 2:1 to 3:1 and results from increased hypoxanthine excretion, in contrast to other hyperuricosuric conditions where ratios of less than one have been reported. Administration of allopurinol (a xanthine-oxidase inhibitor) reduces the excretion of uric acid but results in an equivalent increase in xanthine and hypoxanthine. These features appear to be unique to congenital hyper-uricosuria.

Citations

Sep 1, 1970·Arthritis and Rheumatism
Sep 1, 1976·Journal of Autism and Childhood Schizophrenia·W L Nyhan
Jan 1, 1986·Journal of Inherited Metabolic Disease·R A RoeselF A Hommes
Feb 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·H A Simmonds
Jan 25, 2003·International Journal of Paediatric Dentistry·K FardiN Kotsanos
Aug 30, 1973·The New England Journal of Medicine·P J BenkeN Herrick
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·C S RubinM E Balis
Dec 1, 1968·Archives of Disease in Childhood·C HooftA F De Schaepdryver
Jun 1, 1968·The Journal of Clinical Investigation·M J BradfordM E Balis
Dec 27, 2011·Current Rheumatology Reports·Rosa J TorresH A Jinnah
Oct 1, 1981·International Journal of Oral Surgery·C Scully
Nov 17, 2010·Dental Traumatology : Official Publication of International Association for Dental Traumatology·Aristidis ArhakisNikolaos Kotsanos
Oct 1, 1974·Experimental Cell Research·R P CoxJ Dancis
Jan 1, 1969·The American Journal of Medicine·M J Bradford, V Hrehorovich
Jan 1, 1969·The Journal of Pediatrics·H L Nadler
Jun 16, 2014·Molecular Genetics and Metabolism·Rong FuH A Jinnah
May 11, 2000·Behavior Modification·L Olson, D Houlihan
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Jun 1, 1978·Developmental Medicine and Child Neurology·W L Nyhan
Jun 1, 1968·Journal of Mental Deficiency Research·F E DreifussG L Sheppard

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