Abstract
As a traditional Chinese medicine (TCM), Huangqi Jianzhong Tang (HQJZ) has a good efficacy in treating chronic atrophic gastritis (CAG). Our objective was to determine its mechanism based on the urine comprehensive metabolome. In the study, a metabolomic approach was applied to reveal the efficacy of HQJZ on the constructed CAG rats coupled with proton nuclear magnetic resonance (1 H NMR) and ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF MS). The results showed the regulatory effect of HQJZ on urinary metabolism disorder in CAG rats was similar to the positive drug teprenone. Nineteen and 16 potential biomarkers related to CAG were detected by NMR and UPLC-Q/TOF MS, respectively. Thirty-two urine metabolites were significantly regulated by HQJZ treatment. Combined with MetPA and partial least square regression analysis (PLS-RA), three metabolic pathways of valine, leucine and isoleucine, TCA cycle, and glycine, serine and threonine metabolism were the most relevant pathways for HQJZ treatment. The main mechanism of HQJZ might be due to the balance of energy consumption, inflammatory inhibition, improvement of the immune system and oxidative stress on the constructed CAG rats. Th...Continue Reading
References
Oct 27, 1992·Biochimica Et Biophysica Acta·J ZhangS H Zeisel
Feb 16, 2002·European Journal of Biochemistry·Claus Schnarrenberger, William Martin
Sep 7, 2006·Analytical and Bioanalytical Chemistry·Zhengzheng Pan, Daniel Raftery
Apr 9, 2008·Gastroenterology·Annemarie C de VriesErnst J Kuipers
Feb 14, 2013·Biochimica Et Biophysica Acta·Roberta De SimoneLuisa Minghetti
Jul 10, 2013·Chemistry Central Journal·Tao YiHubiao Chen
Sep 27, 2013·Cell Biochemistry and Biophysics·Muhammad Akram
Jul 11, 2014·World Journal of Gastroenterology : WJG·Naresh Doni Jayavelu, Nadav S Bar
Aug 12, 2014·BMC Biochemistry·Tao YiHu-Biao Chen
Aug 30, 2014·Proteomics·Frédérique CourantBruno Le Bizec
Feb 24, 2015·Journal of Ethnopharmacology·Yi-Na TangHu-Biao Chen
Apr 22, 2015·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Jun 30, 2015·Journal of Pharmaceutical and Biomedical Analysis·Ting WangLing Wang
Oct 20, 2015·The American Journal of Chinese Medicine·Pengcheng WangHaixue Kuang
Dec 15, 2015·Best Practice & Research. Clinical Gastroenterology·Kentaro Sugano
Jan 29, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Yue WeiJin-Xiang Yang
Oct 5, 2016·Journal of Pharmaceutical and Biomedical Analysis·Jiajia CuiGuanhua Du
Dec 20, 2016·CNS Neuroscience & Therapeutics·Ming HuangBo Hu
Jan 17, 2017·Free Radical Biology & Medicine·Olha ZhenyukhSebastián Mas
Apr 14, 2017·United European Gastroenterology Journal·Sangho JeongJames R Goldenring
Apr 16, 2017·BMC Complementary and Alternative Medicine·Yan SunYuanyuan Chen
Apr 19, 2017·Neurochemical Research·Justin E SperringerSusan M Hutson
Jun 14, 2017·BMC Complementary and Alternative Medicine·Lin ZhuHu-Biao Chen
Oct 12, 2017·Frontiers in Pharmacology·Pei LiuJin-Ao Duan
Oct 16, 2018·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Yifei LiChunsheng Li
Dec 14, 2018·Chinese Medicine·Li DuanE-Hu Liu
Apr 12, 2019·Gut and Liver·Yong Hwan KwonDong Ho Lee
Sep 26, 2019·Frontiers in Endocrinology·Wenting Dai, Lei Jiang
Dec 12, 2019·Scientific Reports·Reika ShiratoriShigeki Aoki
Citations
Nov 12, 2020·PloS One·Guo-Xiu ZuHai-Liang Huang
Dec 1, 2020·Expert Review of Gastroenterology & Hepatology·Yiming HaoYiqin Wang
Mar 19, 2021·The Journal of Pharmacy and Pharmacology·Ya-Qin YangXing-Xin Yang
Mar 30, 2021·Biomedical Chromatography : BMC·Zhaohong XiYaozhou Tian
Jul 2, 2021·Experimental and Therapeutic Medicine·Zhanpeng YanFangshi Zhu