Urinary mitochondrial DNA level in non-diabetic chronic kidney diseases

Clinica Chimica Acta; International Journal of Clinical Chemistry
Pascal Zhongping WeiCheuk-Chun Szeto

Abstract

Mitochondrial dysfunction plays an important role in the pathogenesis and progression of chronic kidney disease (CKD). We study the relation between urinary mitochondrial DNA (mtDNA) levels and renal dysfunction in non-diabetic CKD. We recruited 32 CKD patients (20 had hypertensive nephrosclerosis, 12 had IgA nephropathy). Urinary supernatant mtDNA level was measured and compared to baseline clinical and pathological parameters. The patients were followed 57.8 ± 30.5 months for renal function decline. The average urinary supernatant mtDNA level was 222.0 ± 210.3 copy/μL. There was a modest but significant correlation between urinary mtDNA level and proteinuria (Spearman's r = 0.387, p = 0.035), but not any other baseline clinical or pathological parameter. Urinary mtDNA level had a significant inverse correlation with the slope of GFR decline (r = -0.402, p = 0.023). Urinary mtDNA level is a predictor of renal survival even after adjusting for baseline proteinuria with multivariate Cox analysis. In this model, every increase in urinary mtDNA by 100 copy/μL confers a 25.0% increase in risk of doubling of serum creatinine or need of dialysis (95%CI, 0.7% to 55.1%). Mitochondrial DNA is readily detectable in the urinary supernatan...Continue Reading

Citations

Jan 3, 2020·JCI Insight·William Z ZhangUNKNOWN SPIROMICS Investigators
Dec 28, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marcel P B JansenJoris J T H Roelofs
Mar 6, 2019·BMC Nephrology·Cheuk-Chun SzetoPhilip Kam-Tao Li
Nov 7, 2019·Scientific Reports·Byung Chul YuSoon Hyo Kwon
Jul 27, 2021·Oxidative Medicine and Cellular Longevity·Lini JinFei Han

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