PMID: 6985521Mar 1, 1981Paper

Urinary monitoring for diethylstilbestrol in male chemical workers

Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
E Shmunes, D J Burton

Abstract

Between 1969 and 1972 diethylstilbestrol (DES) accounted for 25 instances of breast tenderness and enlargement in male chemical workers in a DES production area of a large chemical plant. A gas chromatographic analysis for urinary DES was performed at three spaced intervals over a 90-day work span. All full-time workers who wore air suits when necessary developed increasing levels of DES upon increasing days of exposure. At a certain range of excretion (40 micrograms/ml/24 hours) two workers became symptomatic. DES was also detected in one helper and in two individuals not directly connected with the area of known exposure. Although no federal standard for DES exists, the following evidence points to the actuality of hazardous levels of exposure: (1) there had been a persistent history of DES reactions year after year; (2) high urine levels and adverse reactions were found in workers participating in the medical studies of this evaluation; and (3) there was widespread DES contamination of buildings and equipment, extending as far away as the lunchroom in a separate building.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Fertility and Sterility
Kimberly M PerezNational Cancer Institute's DES Follow-up Study Group
Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
S S PintoL D White
© 2021 Meta ULC. All rights reserved