Urinary monocyte chemoattractant protein-1 levels and interstitial changes in the renal cortex and their relationship with loss of renal function in renal transplant patients with delayed graft function

Canadian Journal of Kidney Health and Disease
Miguel Moyses NetoTerezila M Coimbra

Abstract

Inflammatory cell infiltration and residual areas of fibrosis in kidneys after renal transplantation can lead to functional abnormalities with long-term implications. The aim of this study was to determine urinary monocyte chemoattractant protein-1 (uMCP-1) levels, relative cortical interstitial area (RCIA), and cortical tubulointerstitial macrophage infiltration in renal transplant patients with delayed graft function (DGF) and their possible correlation with graft outcome. Patients were followed after biopsies for one year, and their renal function and structure were evaluated, as well as parameters of inflammatory process. Clinical Hospital of the School of Medicine of Ribeirão Preto. Twenty-two cadaveric kidney transplant recipients with DGF were followed for one year. Renal function, RCIA, macrophages infiltration and uMCP-1 levels were evaluated. Renal function was evaluated by plasma creatinine levels. RCIA was determined by morphometry. Immunohistochemical staining of macrophages was performed using an anti-CD68 monoclonal antibody. uMCP-1 levels were determined using a human MCP-1/CCL2 immunoassay kit. There was a significant increase in uMCP-1 levels in transplant patients compared with controls (p < 0.001). RCIA was ...Continue Reading

References

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Citations

Mar 15, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rafael N MorescoGuilherme V Bochi
Mar 19, 2013·The Science of the Total Environment·Rim KhlifiAmel Hamza-Chaffai

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