Urinary mutagenicity in chemical laboratory workers exposed to solvents

Journal of Occupational Health
Soraya D VarellaEliana Ap Varanda

Abstract

Solvents represent an important group of environmental pollutants to which people are exposed daily in the workplace. The physico chemical properties of solvents may result in disturbances to cellular structures, including damage to DNA. However, the effects of mixtures of solvents are not well known. Mutations caused by environmental agents are related to cancer development and other degenerative diseases. The work in a research laboratory that uses several types of solvents is equally predisposed to these hazards. In this study, we evaluated the mutagenicity of urine from 29 subjects exposed occupationally to solvents in a chemistry research laboratory and 29 subjects without occupational exposure (controls). Urine samples were collected in polyethylene containers at the end of the work shift. For the concentration and extraction of urine samples the XAD-2 resin was used with acetone as an eluting agent. Several strains of Salmonella typhimurium (TA100, TA98, TA97a, TA1535, YG1024) should be used to assess mutagenic susceptibilities among workers exposed to organic solvents. Different doses of extract (1.5; 3.0; 6.0 and 12.0 ml equivalents of urine per plate) were tested on S. typhimurium strains TA100 and YG1024, with and wi...Continue Reading

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Feb 14, 2013·Environmental Health and Preventive Medicine·Yasuhiro NagasawaMasayuki Ikeda
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May 21, 2017·Occupational and Environmental Medicine·Per GustavssonChristina Reuterwall
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