Urinary N-methylhistamine in asthmatic children receiving azelastine hydrochloride

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
S TakeiK Miyata

Abstract

Histamine has a particular role in the pathogenesis of bronchial asthma, and many antiallergic drugs have been developed with antihistaminic action in mind. Recently, a sensitive and specific assay for measuring histamine and its metabolites has been developed. There are, however, no reports of the effect of antiallergic drugs on histamine levels in asthmatic patients. To determine the relationship between clinical symptoms and histamine levels in asthmatic patients receiving an antiallergic agent. A prospective study was designed in asthmatic children treated with azelastine hydrochloride. The evaluation of clinical symptoms was based on scores of the severity of exacerbations, activities of daily living, quality of sleep, and required therapy. Urinary excretion of N-methylhistamine, a major metabolite of histamine, was measured by double antibody radioimmunoassay. In the patients treated with azelastine, the improvement in clinical symptoms of bronchial asthma correlated significantly with a decrease in urinary N-methylhistamine excretion (r2 = 0.434, P < .001), while no such relationship was noted in patients receiving no antiallergic agent. Urinary N-methylhistamine excretion showed no diurnal change or influence of meals. ...Continue Reading

Citations

Dec 6, 2012·Current Allergy and Asthma Reports·Samuel J Wadsworth, Andrew J Sandford
Jul 28, 2011·Journal of Asthma and Allergy·Sj WadsworthDr Dorscheid
Jul 15, 2015·The Journal of Allergy and Clinical Immunology·Darryl J AdamkoBrian H Rowe
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Erik J SaudeDarryl J Adamko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.