PMID: 8598953Mar 1, 1996Paper

Urinary N-telopeptides to monitor bone resorption while on GnRH agonist therapy

Obstetrics and Gynecology
L A MarshallC H Chesnut

Abstract

To assess the utility of urinary cross-linked N-telopeptides in monitoring bone resorption and predicting bone loss during GnRH agonist administration. Ninety patients who were prescribed GnRH agonist therapy for 3-6 months for treatment of endometriosis, leiomyomas or other gynecologic disorders participated in this prospective multicenter study. N-telopeptides, serum estradiol (E2), and bone mineral density were monitored before, during and up to 3 months after the course of GnRH agonist therapy. N-telopeptide levels increased significantly throughout GnRH agonist therapy and returned to baseline levels by 3 months after treatment was completed. A significant negative correlation was seen between N-telopeptide and E2 measurements after 3 months (r=-0.23, P<.05), 4 months (r=-0.32, P < .05), and 5 months (r=-0.41, P<.005) of GnRH agonist therapy. The percent change in bone mineral density at L1-L4 at 6 months of GnRH agonist treatment correlated inversely with the percent change in N-telopeptides from baseline to 2,3,4, and 5 months of treatment; the percent change of bone mineral density at the femoral neck at 6 months correlated inversely with the percent change of N-telopeptides from baseline to month 4. Urinary N-telopepti...Continue Reading

References

Jul 1, 1987·The Journal of Clinical Endocrinology and Metabolism·J A GudmundssonS J Nillius
Oct 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J S JohansenC Christiansen
Dec 15, 1994·The New England Journal of Medicine·J S FinkelsteinR M Neer
Feb 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B J GertzD R Eyre

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Citations

Feb 10, 1998·Clinical Biochemistry·R H Christenson
May 20, 1998·Fertility and Sterility·U UlrichC H Chesnut
Apr 17, 2008·The Proceedings of the Nutrition Society·Richard Eastell, Rosemary A Hannon
May 26, 2004·Clinics in Laboratory Medicine·Catherine A Hammett-Stabler
Oct 16, 2004·Internal Medicine Journal·P K K WongC White
Sep 18, 2007·Journal of Pediatric and Adolescent Gynecology·Amy D DivastaCatherine M Gordon
Aug 31, 1999·Scandinavian Journal of Gastroenterology·C SchulteH Goebell

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