Urinary neopterin and nitric oxide metabolites as markers of interferon beta-1a activity in primary progressive multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
K RejdakGavin Giovannoni

Abstract

Interferon beta has not been demonstrated to be effective in exploratory phase 2 clinical trials in primary progressive multiple sclerosis. However, using more sensitive indicators of a treatment response, such as biomarkers, might help to identify sub-groups of patients who may benefit from therapy. To assess the utility of measuring urinary neopterin and nitric oxide metabolite excretion for monitoring interferon beta-1a (IFNbeta-1a) treatment in patients with primary progressive multiple sclerosis. Fifty patients from a phase II trial of IFNbeta-1a (Placebo n = 20; Avonex 1 x 30 microg/week (IFN-30), n = 15; Avonex 1 x 60 microg/week (IFN-60), n = 15), were enrolled. Patients were assessed using the Expanded Disability Status Scale. Urine samples were collected on each visit, 3 months apart, for a period of 24 months. Nitric oxide metabolites, nitrite/nitrate (NOx), were measured by colorimetric assay and neopterin and creatinine (Cr) were assayed using a high-performance liquid chromatography technique. NOx/creatinine ratio (NOxCR) and urinary neopterin/creatinine ratio (UNCR) quotients were calculated. There was no significant difference between pre-dose, baseline levels of UNCR or NOxCR between the study groups. On the in...Continue Reading

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Citations

Nov 26, 2010·BMC Infectious Diseases·Angela CannasDelia Goletti
Apr 1, 2012·Multiple Sclerosis and Related Disorders·Ruth Dobson
Jun 29, 2007·Journal of Translational Medicine·Thomas E IchimNeil H Riordan
Jul 9, 2020·Journal of Neurology·Christian LunettaJonica Campolo
Apr 14, 2018·Indian Journal of Clinical Biochemistry : IJCB·Hanaa B AtyaFathia Z El Sharkawi
Mar 15, 2011·Experimental Cell Research·Richard A Rudick, Susan E Goelz
May 3, 2011·Current Opinion in Neurology

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