Urinary nerve growth factor levels are increased in patients with bladder outlet obstruction with overactive bladder symptoms and reduced after successful medical treatment

Urology
Hsin-Tzu Liu, Hann-Chorng Kuo

Abstract

Urinary nerve growth factor (NGF) levels have been shown to be increased in patients with symptoms of overactive bladder (OAB). This study was designed to measure the urinary NGF levels in patients with bladder outlet obstruction (BOO) with or without OAB and to determine whether urinary NGF can serve as a biomarker for OAB. Urinary NGF levels were measured in 38 male control subjects without lower urinary tract symptoms and 153 patients with BOO. The diagnosis of BOO was further classified as BOO/non-OAB (n = 21), BOO/OAB (n = 25), BOO with urodynamically confirmed detrusor overactivity (BOO/DO, n = 47), and BOO/OAB in patients who had received successful medical treatment (n = 60). The urinary NGF levels were measured by enzyme-linked immunosorbent assay and compared among the different groups. The total urinary NGF levels were normalized to the concentration of the urinary creatinine (NGF/Cr) level. The urinary NGF/Cr levels were very low in the control group (mean +/- standard error 0.005 +/- 0.003) and in patients with BOO/non-OAB (0.017 +/- 0.009) and significantly greater in patients with BOO/OAB (0.81 +/- 0.31) and BOO/DO (0.80 +/- 0.13). The urinary NGF/Cr levels were not significantly different between the BOO/OAB and...Continue Reading

Associated Clinical Trials

References

Nov 1, 1991·The Journal of Clinical Investigation·W D SteersJ B Tuttle
Feb 13, 2003·Neurourology and Urodynamics·G Alessandro DigesuStefano Salvatore
Apr 24, 2004·The Journal of Pain : Official Journal of the American Pain Society·K LambK Bielefeldt
Feb 14, 2006·Nature Clinical Practice. Urology·William D Steers, Jeremy B Tuttle
Apr 8, 2006·The Journal of Urology·Joon Chul KimTae-Kon Hwang
Feb 3, 2007·Neurourology and Urodynamics·Lori A BirderNeil M Resnick

❮ Previous
Next ❯

Citations

Jun 22, 2014·Irish Journal of Medical Science·A Korzeniecka-Kozerska, A Wasilewska
Oct 10, 2008·American Journal of Physiology. Renal Physiology·Mary Beth Klinger, Margaret A Vizzard
Dec 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birthe SchnegelsbergDebra A Cockayne
May 8, 2010·Journal of Molecular Neuroscience : MN·Beatrice M GirardMargaret A Vizzard
Nov 5, 2010·American Journal of Physiology. Renal Physiology·Beatrice M GirardMargaret A Vizzard
Sep 28, 2012·Current Urology Reports·Shahin TabatabaeiHenry H Woo
Oct 20, 2015·Expert Opinion on Drug Delivery·Pradeep TyagiNaoki Yoshimura
Jun 19, 2013·Neurourology and Urodynamics·Célia Duarte Cruz
Jan 5, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hsin-Tzu LiuHann-Chorng Kuo
Dec 19, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Antonella GiannantoniConsuelo Amantini
Apr 19, 2011·The Journal of Urology·Apostolos Apostolidis
Nov 8, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoki YoshimuraYasuhito Funahashi
Nov 2, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Kang Jun Cho, Joon Chul Kim
Apr 1, 2011·Lower Urinary Tract Symptoms·Hann-Chorng KuoMichael B Chancellor
Sep 1, 2010·Lower Urinary Tract Symptoms·Hann-Chorng KuoMichael B Chancellor
May 25, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Dong-Ru HoYun-Chin Huang
Mar 1, 2012·Lower Urinary Tract Symptoms·Hann-Chorng Kuo
Jul 23, 2011·Neurourology and Urodynamics·Fawzy F Farag, John P Heesakkers
Apr 27, 2011·Neurourology and Urodynamics·Peter OchodnickýMartin C Michel
Dec 22, 2009·Neurourology and Urodynamics·William C de Groat, Naoki Yoshimura
Jun 21, 2011·Advances in Urology·Tiago Antunes-LopesCarlos Martins-Silva
Jul 22, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Naoki WadaHidehiro Kakizaki
May 14, 2014·Neurourology and Urodynamics·Ching-Chung LiangTsong-Hai Lee
Dec 9, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·B PeyronnetX Gamé
Mar 1, 2014·Korean journal of urology·Naoki YoshimuraPradeep Tyagi
Dec 12, 2017·Current Bladder Dysfunction Reports·Laura Martinez, Rose Khavari
Dec 20, 2017·Frontiers in Systems Neuroscience·Beatrice M GirardMargaret A Vizzard
Oct 10, 2012·Nature Reviews. Urology·Peter OchodnickyFrancisco Cruz
Feb 16, 2011·Nature Reviews. Urology·Rufus CartwrightVik Khullar
Jan 31, 2012·Urologia·Emilio Sacco
Sep 15, 2011·Developmental Neurobiology·Robert W HamillMargaret A Vizzard
Sep 28, 2018·Journal of Molecular Neuroscience : MN·Jacqueline OjalaMargaret A Vizzard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.