PMID: 20646413Jul 22, 2010Paper

Urinary neutrophil gelatinase-associated lipocalin and urinary interleukin-18 in early diagnosis of acute kidney injury in critically ill patients

Zhonghua nei ke za zhi
Zhi-dong ZangHai-bo Qiu

Abstract

To determine whether urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary interleukin-18 (uIL-18) are early markers of acute kidney injury (AKI) in critically ill patients. Ninety-two critically ill patients were studied for one week after their enrollment into our hospital. During the study, 46 patients who met the RIFLE criteria were selected as AKI group and the remaining 46 patients without AKI taken as a control group. The two groups were matched for age, gender and illness severity. Urine samples were collected daily for one week. The receiver operating characteristic curve was used to evaluate the early diagnostic value of uNGAL, uIL-18 and serum creatinine (SCr). As compared with the levels obtained 3 days before the diagnosis of AKI, the uNGAL levels in the AKI group increased significantly (P < 0.05), while uIL-18 and SCr levels did not change 2 days prior to the diagnosis of AKI (all P > 0.05). uNGAL and uIL-18 levels increased significantly (all P < 0.05), while SCr levels did not change 1 day prior to the diagnosis of AKI in the AKI group (P > 0.05). The levels of uNGAL, uIL-18 and SCr did not change significantly in the control group during the study period (all P > 0.05). Three days before the d...Continue Reading

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