Urinary neutrophil gelatinase-associated lipocalin and monocyte chemoattractant protein 1 as biomarkers for lupus nephritis in Colombian SLE patients

Lupus
J A Gómez-PuertaG Vásquez

Abstract

Background Information regarding urinary biomarkers in Mestizo and Afro-Latin-American patients is very limited. We investigated whether levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein 1 (MCP-1) are good biomarkers to differentiate patients with lupus nephritis among Latin-American systemic lupus erythematosus (SLE) patients. Methods SLE patients meeting the revised American College of Rheumatology classification criteria for SLE were recruited. Urinary levels of NGAL and MCP-1 were measured using a commercial ELISA kit. Serum anti-C1q antibodies were measured by ELISA. SLE activity was measured with the systemic lupus erythematosus disease activity index (SLEDAI). Mann-Whitney tests were used to compare data and Spearman's rank correlations were used to examine associations between continuous variables. In addition, receiver operating characteristic curves were performed. Results One hundred and twenty SLE patients were recruited (87% women) with a median age of 32.8 ± 12.1 years and median disease duration of 7.3 ± 6.9 years. Afro-Latin-Americans had a significantly higher prevalence of lupus nephritis and higher SLEDAI scores than Mestizos. The three biomarkers were s...Continue Reading

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Citations

Mar 12, 2019·Expert Review of Proteomics·Najla AljaberiPrasad Devarajan
Jul 14, 2019·Lupus·M F Ugarte-GilG S Alarcón
Dec 15, 2020·Lupus·Luis Alonso GonzálezGraciela S Alarcón
Jul 13, 2021·Cytokine·Soudeh Ghafouri-FardAlireza Salimi

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Methods Mentioned

BETA
biopsy
biopsies
urine collection
ELISA

Software Mentioned

SPSS
GraphPad Prism
GLADEL

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