Urinary nitric oxide metabolite changes in spontaneous and induced onset active labor

Acta Obstetricia Et Gynecologica Scandinavica
Da-Chung ChenGwo-Jang Wu

Abstract

The aim of this prospective, randomized study was to investigate the changes in urinary nitric oxide (NO) metabolite between the latent and the active phases of spontaneous and either prostaglandin E(1) (PGE(1)) or prostaglandin E(2) (PGE(2))-induced labors. Eighty-eight singleton pregnant women at 36-41(+) weeks' gestation without signs of fetal distress were enrolled. The first group consisted of 29 pregnant women in whom labor was induced by PGE(1) applied intravaginally. The second group consisted of 29 pregnant women with labor induced by PGE(2) applied intracervically. The third group consisted of 30 women, who had spontaneous active labor. Clinical data of the three groups were assessed as labor progressed. Urinary nitric oxide/creatinine (U NO/Cr) decreased significantly after the onset of active labor in all three groups (p < 0.005), with the percentage decline of 42.2%, 28.6% and 10.1%, respectively. The magnitude of the difference in decline in U NO/Cr after active labor between the PGE(1)-induced and the spontaneous labor group was significantly reduced (p = 0.0047) after adjustment for potential confounders using the generalized estimating equations test (GEE). The duration of the latent phase was significantly sho...Continue Reading

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Citations

May 19, 2005·Obstetrics and Gynecology Clinics of North America·John B LiaoErrol R Norwitz
Oct 12, 2010·The Cochrane Database of Systematic Reviews·G Justus HofmeyrCynthia Pileggi

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