Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age: The home study.

Environmental Research
Marisa E MillensonKimberly Yolton

Abstract

Prenatal exposure to organophosphate insecticides may be associated with autism spectrum disorders and related behaviors. This association may be modified by single nucleotide polymorphisms in the paraoxonase (PON1) enzyme. We examined the relationship of prenatal organophosphate insecticide biomarkers with reciprocal social, repetitive, and stereotypic behaviors in 8-year old children, and modification of this relationship by child PON1 polymorphisms. Among 224 pregnant women, we quantified concentrations of six nonspecific dialkyl phosphate (DAP) metabolites of organophosphate insecticides in two urine samples collected at ~16 and ~26 weeks gestation. When children were eight years old, we administered the Social Responsiveness Scale (SRS), a continuous measure of various dimensions of interpersonal behavior, communication, and repetitive/stereotypic behaviors. We estimated the association between a 10-fold increase in the sum of six DAP concentrations (ΣDAP) and SRS scores. We examined whether child PON1192 and PON1-108 genotypes modified this association. After covariate adjustment, ΣDAP concentrations were not associated with SRS scores [β=-1.2; 95% confidence interval (CI): -4.0, 1.6]. Among children with the PON1-108TT g...Continue Reading

Citations

May 2, 2019·Environmental Science and Pollution Research International·Ratana Sapbamrer, Surat Hongsibsong
Dec 19, 2019·Environmental Science and Pollution Research International·Tahereh FarkhondehOmid Mehrpour
Oct 25, 2017·Current Environmental Health Reports·Nicole Comfort, Diane B Re
Mar 20, 2018·Journal of Autism and Developmental Disorders·MacKinsey A ChristianMohammad H Rahbar
Jan 28, 2021·Antioxidants·Ignazio Stefano PirasAntonio M Persico
Jun 3, 2021·International Journal of Environmental Research and Public Health·Judit Biosca-BrullMaria Teresa Colomina
Mar 30, 2021·American Journal of Epidemiology·Joshua D AlampiLawrence C McCandless

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