Urinary orosomucoid 1 protein to creatinine ratio as a potential biomarker for early screening of kidney impairment in type-2 diabetes patients.

Nephrology
Huabin WangCaiqun Huang

Abstract

Early screening of diabetic kidney disease (DKD) remains a major challenge. Our aim was to evaluate the value of urinary orosomucoid 1 protein (UORM1) in early renal impairment screening in type-2 diabetes patients. The concentration of UORM1, the UORM1-to-creatinine ratio (UORM1CR), the urinary albumin-to-creatinine ratio (ACR), the alpha-1-microglobulin-to-creatinine ratio (A1MCR) and estimated glomerular filtration rate (eGFR) were measured in 406 type-2 diabetes patients. Any positive values for ACR, A1MCR and/or eGFR were considered as indicative of renal impairment. On average, the levels of UORM1 and UORM1CR were about seven times higher in subjects with renal injury than in those without. Both UORM1 and UORM1CR, when adjusted via logarithm-transformation, were significantly related to ACR, A1MCR and eGFR levels. The highest correlation was observed between UORM1CR and A1MCR (r = 0.85, P < .001). The cut-off values for UORM1 (2.53 mg/L) and UORM1CR (3.69 mg/g) for the early diagnosis of kidney impairment were obtained from receiver operating characteristic curves. UORM1CR obviously had higher diagnostic efficiency corresponding to 83.26% sensitivity and 90.32% specificity than UORM1. Likewise, its sensitivity was higher ...Continue Reading

References

Mar 1, 1983·Journal of Clinical Pathology·H YuI C MacLennan
Nov 4, 2000·Biochimica Et Biophysica Acta·T FournierD Porquet
Oct 16, 2004·Kidney International. Supplement·Jacobien C VerhaveUNKNOWN PREVEND Study Group
May 30, 2006·Diabetes·Ravi RetnakaranUNKNOWN UKPDS Study Group
Feb 16, 2007·Journal of the American Society of Nephrology : JASN·Sanju A VargheseJohn M Arthur
Oct 31, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·M S ChristiansenB Feldt-Rasmussen
Jul 9, 2011·Journal of Hypertension·Giuseppe PennoUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Aug 31, 2011·Metabolic Syndrome and Related Disorders·Edgar G Duran-PerezFrancisco J Gomez-Perez
Oct 17, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·UNKNOWN National Kidney Foundation
Jun 30, 2015·Diabetes Research and Clinical Practice· Idf Diabetes Atlas Group
Jul 29, 2015·International Urology and Nephrology·Hua-Bin WangRui Liu
Aug 5, 2015·Journal of Clinical Medicine·Radovan HojsNina Hojs
Dec 16, 2016·Nephron·Roberto Trevisan, Alessandro Roberto Dodesini
May 23, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Digsu N KoyeJonathan E Shaw
Aug 31, 2018·Mediators of Inflammation·Agnieszka ŻyłkaMarek Kuźniewski
May 13, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Huabin WangXiaoyun Shan
Jun 1, 2016·Academic Forensic Pathology·Mariana Moreno Prats, Judith F Aronson

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