Urinary PGE-M Levels and Risk of Ovarian Cancer

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Mollie E BarnardShelley S Tworoger

Abstract

Regular aspirin use may lower ovarian cancer risk by blocking the cyclooxygenase enzymes, resulting in lower expression of prostaglandins, including prostaglandin E2 (PGE2). We evaluated whether higher prediagnosis PGE-M (a urinary biomarker of PGE2) was associated with increased ovarian cancer risk in three prospective cohorts. We conducted a case-control study nested in the Nurses' Health Study (NHS), NHSII, and Shanghai Women's Health Study. Our analyses included 304 cases of epithelial ovarian cancer diagnosed from 1996 to 2015 and 600 matched controls. We measured urinary PGE-M using LC/MS with normalization to creatinine. Measures from each study were recalibrated to a common standard. We estimated ORs and 95% confidence intervals (CI) using conditional logistic regression, with PGE-M levels modeled in quartiles. Multivariable models were adjusted for ovarian cancer risk factors. There was no evidence of an association between urinary PGE-M levels and ovarian cancer risk for women with PGE-M levels in the top versus bottom quartile (OR = 0.80; 95% CI, 0.51-1.27; Ptrend = 0.37). We did not observe heterogeneity by histotype (P = 0.53), and there was no evidence of effect modification by body mass index (Pinteraction = 0.82...Continue Reading

References

Apr 1, 1975·The Journal of Clinical Investigation·J C FrölichJ A Oates
May 8, 1998·The American Journal of Medicine·J R Vane, R M Botting
Mar 14, 2002·The American Journal of Pathology·Carsten DenkertSteffen Hauptmann
Aug 16, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FerrandinaG Scambia
Nov 1, 2003·Thrombosis Research·J R Vane, R M Botting
Jun 21, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yuko KinoShinichi Kawai
Jul 21, 2005·Journal of the National Cancer Institute·Eva S Schernhammer, Susan E Hankinson
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Neil D GrossAnna J Duffield-Lillico
Oct 21, 2005·American Journal of Epidemiology·Wei ZhengYu-Tang Gao
Feb 24, 2006·Nature Reviews. Cancer·Cornelia M UlrichJohn D Potter
Sep 26, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·J Chad JohnsonNipun B Merchant
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiuyin CaiWei Zheng
Jul 28, 2007·American Journal of Epidemiology·Shelley S TworogerSusan E Hankinson
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ralph S FreedmanRobert A Newman
Jul 18, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jason R Neale, Brian J Dean
Oct 29, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda M DongChristian C Abnet
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Emanuela Ricciotti, Garret A FitzGerald
Dec 12, 2012·Journal of the National Cancer Institute·A Heather EliassenSusan E Hankinson
Dec 18, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Louise BaandrupSusanne K Kjaer
Mar 4, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Linda KortzUta Ceglarek
Sep 13, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yong CuiWei Zheng
Dec 30, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BaandrupS Friis
Jan 6, 2015·International Journal of Cancer. Journal International Du Cancer·Zhezhou HuangAlicia Beeghly-Fadiel
Oct 24, 2015·International Journal of Colorectal Disease·S AmorM Granado
Feb 26, 2016·British Journal of Cancer·Lauren C PeresJoellen M Schildkraut
Feb 26, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sandi L NavarroEmily White
Mar 13, 2016·Seminars in Oncology·Asad UmarErnest T Hawk
Jun 10, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Fangfang ZengXuefen Su
Apr 13, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tianyi WangMeira Epplein
Aug 18, 2017·International Journal of Cancer. Journal International Du Cancer·Yong CuiWei Zheng
Feb 28, 2018·Journal of Ovarian Research·Alicia Beeghly-FadielDineo Khabele
Jun 4, 2018·Journal of the National Cancer Institute·Britton TrabertUNKNOWN Ovarian Cancer Cohort Consortium (OC3)
Sep 29, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Manila HadaBritton Trabert

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Citations

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