PMID: 46182Feb 1, 1975

Urinary polyamine levels in human cancer

Cancer
A LiptonG F Kessler

Abstract

Polyamine levels (putrescine, spermidine, spermine) were determined in 24-hour urine samples by a high voltage electrophoresis technique. Normal values were established in 42 normal volunteers. Thirty-eight of 56 patients with metastatic cancer had two or more levels elevated. Approximately two-thirds of patients with metastatic adenocarcinoma, metastatic squamous cell cancer or metastatic disease to the liver, lings, or bones had elevated levels. All 6 patients with localized malignant tumors had elevated urinary polyamine levels. Elevations were also seen in patients with benign prostatic hypertrophy and bronchial adenoma.

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Related Concepts

Adenoma, Trabecular
Dermatofibrosarcoma Protuberans
Squamous Cell Neoplasms
Malignant Bone Neoplasm
Neoplasms
Putrescine
Malignant Tumor of Colon
Spermine
Malignant Mixed Tumor
Adenocarcinoma

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