Urinary polyamine levels in human cancer
Polyamine levels (putrescine, spermidine, spermine) were determined in 24-hour urine samples by a high voltage electrophoresis technique. Normal values were established in 42 normal volunteers. Thirty-eight of 56 patients with metastatic cancer had two or more levels elevated. Approximately two-thirds of patients with metastatic adenocarcinoma, metastatic squamous cell cancer or metastatic disease to the liver, lings, or bones had elevated levels. All 6 patients with localized malignant tumors had elevated urinary polyamine levels. Elevations were also seen in patients with benign prostatic hypertrophy and bronchial adenoma.
Urinary polyamine excretion by tumor-bearing and tumor-free mice exposed to cyclophosphamide, 5-fluorouracil and 6-mercaptopurine
Sensitive amperometric biosensor for the determination of biogenic and synthetic amines using pea seedlings amine oxidase: a novel approach for enzyme immobilisation
A clinical study of urine basic fetoprotein and urine polyamine as tumor markers in epithelial cancer of the urinary tract
An improved method for routine analysis of polyamines in biological fluids with a conventional amino acid analyzer
Polyamine metabolism I: Synthesis of dansyl derivatives of N-(monoaminoalkyl)- and N-(polyaminoalkyl)acetamides and elucidation in urine of a cancer patient
The value of urinary polyamine assay in stomach cancer. Comparison with serum carcinoembryonic antigen
Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors
Putrescine and spermidine biosynthesis in the development of normal and anucleolate mutants of Xenopus laevis
Amine synthesis in regenerating rat liver: effect of hypophysectomy and growth hormone on ornithine decarboxylase
Carcinoma, Squamous Cell
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