PMID: 6981163Mar 1, 1982Paper

Urinary prophylaxis with trimethoprim and trimethoprim-sulfamethoxazole: efficacy, influence on the natural history of recurrent bacteriuria, and cost control

Reviews of Infectious Diseases
W E StammK K Holmes

Abstract

Low-dose trimethoprim (TMP), trimethoprim-sulfamethoxazole (TMP-SMZ), and nitrofurantoin macrocrystals were found to be safe and effective as prophylaxis against recurrent urinary tract infections. Women given placebo had 2.8 infections per patient-year during the six-month study period, while women given TMP, TMP-SMZ, or nitrofurantoin had significantly lower infection rates (0.015 per patient-year). The effect of prophylaxis appeared to be limited to the period when the agents were taken. Only one patient had a TMP-resistant coliform isolated from cultures obtained during prophylaxis and six months afterwards. The sole factor associated with the recurrence of infection after prophylaxis was a history of three or more infections in the year preceding prophylaxis. Thirty-one of the 60 women in the trial were monitored for a mean of 6.1 years before and 3.2 years after they entered the study. Analysis of infection rates indicated that about half these women were experiencing an infection cluster when they entered the study and that the prestudy baseline infection rate correlated with the poststudy rate. Thus, prophylaxis did not appear to exert a long-term effect on the baseline infection rate. Urinary prophylaxis generally appe...Continue Reading

Citations

Feb 9, 1984·The New England Journal of Medicine·A L Komaroff
Nov 1, 1987·Mayo Clinic Proceedings·M P Wilhelm, R S Edson
May 20, 2008·Obstetrics and Gynecology Clinics of North America·Raymond T Foster
May 15, 1984·The American Journal of Medicine·W E Stamm
Feb 26, 1999·The Journal of Urology·A J Schaeffer, B A Stuppy
Dec 15, 2004·Pathologie-biologie·Y Le NormandM F Kergueris
Aug 21, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A E MullerA Huttner
Jul 22, 2004·The Cochrane Database of Systematic Reviews·X AlbertC Perrota
Feb 15, 1987·Postgraduate Medicine·A J Schaeffer
Jul 21, 2006·Enfermedades infecciosas y microbiología clínica·Carlos Pigrau-Serrallach

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