Urinary prostaglandin metabolites as Duchenne muscular dystrophy progression markers

Brain & Development
Eri TakeshitaMasayuki Sasaki

Abstract

Patients with Duchenne muscular dystrophy (DMD) exhibit increased prostaglandin D2 (PGD2) expression in necrotic muscle and increased PGD2 metabolites in their urine. In mouse models, inhibiting PGD2 production suppresses muscle necrosis, suggesting a possible intervention through PGD2-mediated activities. We investigated the involvement of PGD2 and its potential use as a marker of pathological progression in DMD. Sixty-one male children with DMD and thirty-five age-matched controls were enrolled in the study. DMD patients were divided into "ambulant" and "non-ambulant" groups, which were further subdivided into "steroid" and "non-steroid" therapy groups. Levels of the PGD2 metabolite tetranor-PGDM (t-PGDM) and creatinine were measured in both spot and 24-hour urine samples, with comparisons between groups made according to geometric mean values. DMD patients had significantly higher levels of creatinine-corrected t-PGDM in spot urine samples as compared with the control group. Additionally, both ambulant and non-ambulant DMD groups had significantly higher levels of t-PGDM as compared with controls, with no significant difference in t-PGDM levels observed between steroid and non-steroid groups. Moreover, total creatinine excre...Continue Reading

Citations

Jan 21, 2020·Annals of Clinical and Translational Neurology·Hirofumi KomakiShin'ichi Takeda
Jan 6, 2021·International Journal of Molecular Sciences·Victor Corasolla CarregariGiorgio Tasca
Jun 7, 2021·Cellular and Molecular Life Sciences : CMLS·Urszula Florczyk-SoluchJózef Dulak
May 18, 2021·Journal of Immunology Research·Nanae NagataTakahisa Murata
Sep 24, 2021·Pflügers Archiv : European journal of physiology·Kay Ohlendieck, Dieter Swandulla

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