Urinary protein excretion and expectant management of early onset, severe pre-eclampsia

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
D R HallD Grové

Abstract

To evaluate the importance of proteinuria in the expectant management of early onset, severe pre-eclampsia. In this prospective series of 340 women, 24-h urine collections were performed and monitored twice weekly in a high-care ward. Seventy-four women with at least two 24-h urine collections were grouped into women with a proteinuria increase of > or =2 g (n=29) and with women whose proteinuria decreased, or increased by <2 g (n=45). Major maternal complications, prolongation of gestation, and perinatal outcomes were comparable. Fifty-six (75%) women experienced an increase in proteinuria. When patients with heavy proteinuria (n=83) were compared to those with moderate proteinuria (n=257), maternal and perinatal outcomes were comparable. More days were gained before delivery in the heavy proteinuria group than in the moderate (12 vs. 9; P<0.001). Most patients experienced increased proteinuria. Neither the rate of increase nor the amount of proteinuria affected maternal and perinatal outcomes.

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Citations

Mar 26, 2009·BMC Medicine·Shakila ThangaratinamKhaled M K Ismail
Jun 18, 2004·Obstetrics and Gynecology Clinics of North America·Anthony R Gregg
Feb 19, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Umran Kucukgoz GulecIsmail Cuneyt Evruke
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