Urinary proteomic biomarkers to predict cardiovascular events

Proteomics. Clinical Applications
Catriona E BrownC Delles

Abstract

We have previously demonstrated associations between the urinary proteome profile and coronary artery disease (CAD) in cross-sectional studies. Here, we evaluate the potential of a urinary proteomic panel as a predictor of CAD in the hypertensive atherosclerotic cardiovascular disease (HACVD) substudy population of the Anglo-Scandinavian Cardiac Outcomes Trial study. Thirty-seven cases with primary CAD endpoint were matched for sex and age to controls who had not reached a CAD endpoint during the study. Spot urine samples were analyzed using CE coupled to Micro-TOF MS. A previously developed 238-marker CE-MS model for diagnosis of CAD (CAD238 ) was assessed for its predictive potential. Sixty urine samples (32 cases; 28 controls; 88% male, mean age 64 ± 5 years) were analyzed. There was a trend toward healthier values in controls for the CAD model classifier (-0.432 ± 0.326 versus -0.587 ± 0.297, p = 0.170), and the CAD model showed statistical significance on Kaplan-Meier survival analysis p = 0.021. We found 190 individual markers out of 1501 urinary peptides that separated cases and controls (AUC >0.6). Of these, 25 peptides were also components of CAD238 . A urinary proteome panel originally developed in a cross-sectional s...Continue Reading

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Citations

Feb 24, 2016·Proteomics. Clinical Applications·von Zur Mühlen CPeter K
Mar 9, 2017·PloS One·Nay M HtunKarlheinz Peter
Apr 8, 2018·Cardiovascular Diabetology·Gemma E CurrieChristian Delles
Apr 4, 2018·Proteomics. Clinical Applications·Pedro MagalhãesLars Pape
Oct 19, 2017·Expert Review of Proteomics·Sarah Röthlisberger, Johanna Pedroza-Diaz
Jul 13, 2018·Expert Review of Proteomics·Christian DellesStuart A Nicklin
Jan 29, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Claudia CalcagnoZahi A Fayad
Feb 27, 2019·Analytical and Bioanalytical Chemistry·Haidan SunYong Zeng
Jul 28, 2020·Proteomics. Clinical Applications·Agnieszka LatosinskaJoost P Schanstra
Oct 27, 2016·Electrophoresis·Anna TýčováKarel Klepárník
Dec 21, 2016·Expert Review of Proteomics·Marika MokouHarald Mischak
May 28, 2016·Expert Review of Proteomics·Michael HarpoleVirginia Espina

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