Urinary Proteomics Profiles Are Useful for Detection of Cancer Biomarkers and Changes Induced by Therapeutic Procedures

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Emanuele FerrariPier Luigi Mauri

Abstract

Boron neutron capture therapy (BNCT) is a binary cancer treatment modality where two different agents (10B and thermal neutrons) have to be present to produce an effect. A dedicated trial design is necessary for early clinical trials. The concentration of 10B in tissues is an accepted surrogate to predict BNCT effects on tissues. Tissue, blood, and urines were sampled after infusion of two different boron carriers, namely BSH and BPA in the frame of the European Organisation for Research and Treatment of Cancer (EORTC) trial 11001. In this study, urine samples were used to identify protein profiles prior and after drug infusion during surgery. Here, an approach that is based on the mass spectrometry (MS)-based proteomic analysis of urine samples from head and neck squamous cell carcinoma (HNSCC) and thyroid cancer patients is presented. This method allowed the identification of several inflammation- and cancer-related proteins, which could serve as tumor biomarkers. In addition, changes in the urinary proteome during and after therapeutic interventions were detected. In particular, a reduction of three proteins that were involved in inflammation has been observed: Galectin-3 Binding Protein, CD44, and osteopontin. The present w...Continue Reading

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Citations

Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paolo Iadarola
Jun 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Afshan MasoodAssim A Alfadda
Feb 26, 2020·PeerJ·Yameng ZhangYouhe Gao
Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Goyeun YunHookeun Lee
Jan 23, 2021·EMBO Molecular Medicine·Sebastian Virreira WinterMatthias Mann
May 1, 2021·Life·Wolfgang A G SauerweinAndrea Wittig

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Methods Mentioned

BETA
neutron capture therapy
ubiquitination
gamma ray
two-dimensional microchromatography

Software Mentioned

Proteome Discoverer
DAVE
Bioworks
Venny
MAProMa
MudPIT
Sequest HT
SEQUEST
DAVID
MAProMa ( Multidimensional Algorithm Protein Map )

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