Urinary pseudouridine in patients with lymphoma: comparison with other clinical parameters

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yasufumi MasakiHisanori Umehara

Abstract

Some patients with malignant lymphoma do not manifest superficial lymphadenopathy. In such cases, clinical parameters that indicate the number of tumor cells are important for the assessment of tumor growth and choice of proper treatment. We evaluated urinary pseudouridine (U-PU) as an indicator of the growth of malignant lymphoma by comparing its levels with serum concentrations of other clinical parameters in patients with various lymphomas at various stages. Urine was obtained from 67 patients with lymphoma. U-PU was assayed by recombinant Fab-based inhibition ELISA. Serum soluble IL2 receptor (sIL2R), serum deoxythymidine kinase (dTK), serum beta-2 microglobulin (beta2MG) and serum lactate dehydrogenase (LDH) were also assayed. U-PU concentrations showed good correlations with serum concentrations of beta2MG, LDH, sIL2R and dTK. The level of U-PU was higher in stage IV than in stages I (P=0.023), II (P=0.006) and III (P=0.036). U-PU concentration correlates with the clinical stage of lymphoma and is a useful tool to assess the growth of lymphoma.

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Citations

Oct 12, 2010·European Journal of Applied Physiology·Daniela AlberghinaGiuseppe Lazzarino
Feb 1, 2008·Expert Opinion on Medical Diagnostics·Ondrej Topolcan, Lubos Holubec
Aug 20, 2010·Journal of Pharmaceutical and Biomedical Analysis·Ewa SzymańskaRoman Kaliszan
Aug 21, 2010·The Biochemical Journal·Alice PreumontEmile Van Schaftingen
Aug 15, 2017·Metabolomics : Official Journal of the Metabolomic Society·Clara Pérez-RamblaAntonio Pineda-Lucena
Jul 28, 2020·Urologic Oncology·Jennifer A StockertAshutosh K Tewari

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