Urinary Titin Is Increased in Patients After Cardiac Surgery

Frontiers in Cardiovascular Medicine
Jun TanihataSusumu Minamisawa

Abstract

Background: Few non-invasive biomarkers have been used to detect myocardial injury in patients with heart diseases. Recently, the N-terminal fragment (N-titin) of titin, a giant sarcomeric protein, which is involved in muscular passive tension and viscoelasticity, has been reported to detect muscle damage in patients with cardiomyopathy as well as in patients with skeletal muscle dystrophy and in healthy volunteers with endurance exercise. In the present study, we evaluated whether urinary N-titin is changed during a perioperative period and whether its increase reflects myocardial damage. Materials and Methods: In 18 patients who underwent cardiac surgery, blood and urine samples were obtained before and after surgery. We measured the urinary levels of N-titin with a highly sensitive ELISA system. Results: Urinary N-titin to creatinine (N-titin/Cr) was significantly increased in all patients postoperatively (43.3 ± 39.5 pmol/mg/dL on the day of operation) and remained significantly high for at least 4 days postoperatively. Urinary N-titin/Cr was positively correlated with serum cardiac troponin T (r = 0.36, p = 0.0006, n = 90) but not creatine kinase-MB (CK-MB). We also found that urinary N-titin/Cr in patients after a coronar...Continue Reading

References

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May 18, 2004·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Brit DybdahlAnders Sundan
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Mar 11, 2018·The American Journal of Cardiology·Akiomi YoshihisaYasuchika Takeishi

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Citations

Oct 7, 2020·Annual Review of Pharmacology and Toxicology·Konrad Teodor SawickiAlessandra Ghigo
Dec 19, 2020·Journal of Strength and Conditioning Research·Yoko TanabeHideyuki Takahashi
Oct 9, 2020·American Journal of Respiratory and Critical Care Medicine·Hidehiko NakanoKensuke Nakamura

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
coronary artery bypass
Urine Sample Collection
ELISA
Assay
the

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