Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat

Journal of Applied Toxicology : JAT
G O RankinP I Brown

Abstract

Phensuximide is a succinimide antiepileptic drug useful in the treatment of petit mal epilepsy. Phensuximide has been reported to be nephrotoxic in man but not in animals. In the present study, the effects of single and subacute administration for seven days of phensuximide on renal function and urinary tract morphology were evaluated in Sprague-Dawley and Fischer 344 rats. Single administration of phensuximide (1.25 mmol/kg, ip) induced mild changes in renal function (trace hematuria, increased proteinuria and decreased p-aminohippurate uptake). No morphological changes were observed at 24 hr. Subacute administration of phensuximide (0.6 mmol/kg/day, ip) produced diuresis in the Sprague-Dawley rat, but little functional evidence of nephrotoxicity. Renal morphological changes in Sprague-Dawley rats were seen primarily in distal segments of the nephrons. These changes were characterized by distensions of the basal infoldings, apical protrusions, and occlusion of some lumen. In the Fischer 344 rat, subacute phensuximide administration (0.3 or 0.6 mmol/kg/day, ip) resulted in transient hematuria and proteinuria, but no change in the other renal function parameters studied. Renal morphological changes observed in Fischer 344 rats o...Continue Reading

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Citations

Sep 17, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary O Rankin
Sep 9, 2015·Organic Letters·Kiran R BettadapurKandikere Ramaiah Prabhu
May 26, 2017·Chemical Communications : Chem Comm·Kiran R BettadapurKandikere Ramaiah Prabhu
Aug 1, 1989·Journal of Applied Toxicology : JAT·G O RankinP I Brown
Apr 1, 1990·Journal of Applied Toxicology : JAT·G O RankinP I Brown
Jul 23, 2015·Beilstein Journal of Organic Chemistry·Dnyaneshwar N GaradSantosh B Mhaske
Jun 26, 2013·Acta Crystallographica. Section E, Structure Reports Online·Tetiana MatviiukChristian Lherbet

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