Urinary tract infections in the elderly: a review of disease characteristics and current treatment options

Drugs in Context
Leocadio Rodriguez-Mañas

Abstract

Urinary tract infections (UTIs) are common in the elderly, and cover a range of conditions from asymptomatic bacteriuria to urosepsis. Risk factors for developing symptomatic UTIs include immunosenescence, exposure to nosocomial pathogens, multiple comorbidities, and a history of UTIs. European guidelines on urological infections recommend antimicrobial treatment only for symptomatic UTIs. Non-antimicrobial options to treat and prevent UTIs include among others cranberry products, OM-89 Escherichia coli bacterial lysate vaccine, and estrogen therapy in postmenopausal women, although evidence for their efficacy is weak. Another non-antimicrobial option to control and prevent UTIs is a medical device (Utipro Plus®) containing xyloglucan, gelatin, propolis, and extracts of Hibiscus sabdariffa. The device acts in the intestine as a mechanical barrier to protect against invasion by uropathogenic E. coli strains. A randomized controlled trial of Utipro Plus® in patients with uncomplicated UTIs provided good-quality evidence of its efficacy compared with placebo. In an observational study of Utipro Plus® in patients with recurrent UTIs, more than 80% women reported a return to their pre-UTI clinical status and about 30% transitioned f...Continue Reading

Citations

Jun 3, 2021·Antibiotics·Răzvan-Cosmin PetcaCălin Bogdan Chibelean
Aug 6, 2021·European Journal of Medical Research·H FischerK F Braun
Aug 24, 2021·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·E Seizilles de MazancourtF Bruyere

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Utipro

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